Anti-Bcl10 Antibody | Boster Immunoleader PB9525 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Bcl10 Antibody

catalog :

PB9525

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Bcl10 Antibody

Catalog Number :

PB9525

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for B-cell lymphoma/leukemia 10(BCL10) detection. Tested with WB in Human;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human Bcl10 recombinant protein (Position: M1-Q233). Human Bcl10 shares 91% and 91.4% amino acid (aa) sequence identity with mouse and rat Bcl10, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. And this protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Reference :

1. Ruland, J., Duncan, G. S., Elia, A., del Barco Barrantes, I., Nguyen, L., Plyte, S., Millar, D. G., Bouchard, D., Wakeham, A., Ohashi, P. S., Mak, T. W.Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappa-B and neural tube closure.Cell 104: 33-42, 2001. 2. Willis, T. G., Jadayel, D. M., Du, M.-Q., Peng, H., Perry, A. R., Abdul-Rauf, M., Price, H., Karran, L., Majekodunmi, O., Wlodarska, I., Pan, L., Crook, T., Hamoudi, R., Isaacson, P. G., Dyer, M. J. S.Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor typesCell 96: 35-45, 1999. 3. Xue, L., Morris, S. W., Orihuela, C., Tuomanen, E., Cui, X., Wen, R., Wang, D.Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells.Nature Immun. 4: 857-865, 2003.

Gene Name :

BCL10

Protein Name :

B-cell lymphoma/leukemia 10

Gene Full Name :

B-cell CLL/lymphoma 10

Synonyms :

AI132454 antibody B cell CLL/lymphoma 10 antibody B cell lymphoma/leukemia10 antibody B-cell CLL/lymphoma 10 antibody B-cell leukemia/lymphoma 10 antibody B-cell lymphoma/leukemia 10 antibody Bcl 10 antibody Bcl-10 antibody Bcl10 antibody BCL10_HUMAN antibody c E10 antibody c-E10 antibody C81403 antibody CARD containing apoptotic signaling protein antibody CARD containing molecule enhancing NF kappa B antibody CARD containing molecule enhancing NF kB antibody CARD containing molecule enhancing NF-kB antibody CARD containing molecule enhancing NFkB antibody CARD containing proapoptotic protein antibody CARD like apoptotic protein antibody CARD-containing apoptotic signaling protein antibody CARD-containing molecule enhancing NF-kappa-B antibody CARD-containing proapoptotic protein antibody CARD-like apoptotic protein antibody CARMEN antibody Caspase recruiting domain containing protein antibody caspase-recruiting domain-containing protein antibody cCARMEN antibody cE 10 antibody cE10 antibody CED 3/ICH 1 prodomain homologous E10 like regulator antibody CED-3/ICH-1 prodomain homologous E10-like regulator antibody CED3/ICH1 prodomain homologous E10 like regulator antibody Cellular E10 antibody Cellular homolog of vCARMEN antibody Cellular-E10 antibody CIPER antibody CLAP antibody hCLAP antibody Mammalian CARD containing adapter molecule E10 antibody Mammalian CARD-containing adapter molecule E10 antibody mE 10 antibody mE10 antibody R-RCD1 antibody

Uniprot ID :

O95999

more info or order :

Boster Immunoleader product webpage