Anti-TNF Receptor II Antibody | Boster Immunoleader PB9514 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-TNF Receptor II Antibody

catalog :

PB9514

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-TNF Receptor II Antibody

Catalog Number :

PB9514

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) detection. Tested with WB in Human;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human TNF Receptor II (288-318aa KKKPLCLQREAKVPHLPADKARGTQGPEQQH), different from the related mouse sequence by eleven amino acids, and from the related rat sequence by ten amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.

Reference :

1. Milatovich, A.; Song, K.; Heller, R. A.; Francke, U. : Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat. Cell Molec. Genet. 17: 519-523, 1991. 2. Vielhauer, V.; Stavrakis, G.; Mayadas, T. N. : Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J. Clin. Invest. 115: 1199-1209, 2005.

Gene Name :

TNFRSF1B

Protein Name :

Tumor necrosis factor receptor superfamily member 1B

Gene Full Name :

tumor necrosis factor receptor superfamily, member 1B

Synonyms :

CD 120b antibody CD120b antibody CD120b antigen antibody Etanercept antibody p75 antibody p75TNFR antibody p80 TNF alpha receptor antibody p80 TNF-alpha receptor antibody TBP-2 antibody TBP2 antibody TBPII antibody TNF R II antibody TNF R2 antibody TNF R75 antibody TNF-R2 antibody TNF-RII antibody TNFBR antibody TNFR 2 antibody TNFR-II antibody TNFR2 antibody TNFR75 antibody TNFR80 antibody TNFRII antibody TNFRSF 1B antibody TNFRSF1B antibody TNR1B antibody TNR1B_HUMAN antibody Tumor necrosis factor beta receptor antibody Tumor necrosis factor binding protein 2 antibody Tumor necrosis factor receptor 2 antibody Tumor necrosis factor receptor superfamily member 1B precursor antibody Tumor necrosis factor receptor type II antibody Tumor necrosis factor-binding protein 2 antibody

Uniprot ID :

P20333

more info or order :

Boster Immunoleader product webpage