Anti-PINX1 Antibody | Boster Immunoleader PB9498 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-PINX1 Antibody

catalog :

PB9498

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-PINX1 Antibody

Catalog Number :

PB9498

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1(PINX1) detection. Tested with WB in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1 (54-83aa DHIKVQVKNNHLGLGATINNEDNWIAHQDD), different from the related mouse and rat sequences by three amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.

Reference :

1. Banik, S.S.R.; Counter, C.M. (September 2004). "Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR". Journal of Biological Chemistry. 2. Zhou, X Z; Lu K P (Nov 2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell (United States) 107 (3): 347–59.

Gene Name :

PINX1

Protein Name :

PIN2/TERF1-interacting telomerase inhibitor 1

Gene Full Name :

PIN2/TERF1 interacting, telomerase inhibitor 1

Synonyms :

67-11-3 protein antibodyFLJ20565 antibody Hepatocellular carcinoma-related putative tumor suppressor antibody Liver-related putative tumor suppressor antibody LPTL antibody LPTS antibody MGC8850 antibody OTTHUMP00000224984 antibody OTTHUMP00000224985 antibody OTTHUMP00000224986 antibody OTTHUMP00000225053 antibody OTTHUMP00000225054 antibody PIN2 interacting protein 1 antibody Pin2-interacting protein X1 antibody PIN2/TERF1-interacting telomerase inhibitor 1 antibody PINX1 antibody PINX1_HUMAN antibody Protein 67-11-3 antibody TRF1-interacting protein 1 antibody

Uniprot ID :

Q96BK5

more info or order :

Boster Immunoleader product webpage