Anti-ITCH/AIP4 Antibody | Boster Immunoleader PB9496 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-ITCH/AIP4 Antibody

catalog :

PB9496

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-ITCH/AIP4 Antibody

Catalog Number :

PB9496

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase Itchy homolog(ITCH) detection. Tested with WB in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human ITCH/AIP4 (410-437aa AMQQFNQRFIYGNQDLFATSQSKEFDPL), different from the related mouse sequence by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

ITCH is an ubiquitin-conjugating enzyme. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Reference :

1. Dorjbal B; Derse D; Lloyd P; Soheilian F; Nagashima K; Heidecker G. “The role of ITCH protein in human T-cell leukemia virus type 1 release”. J Biol Chem, 2011 Sep 9. 2. Rossi M; Inoue S; Walewska R; Knight RA; Dyer MJ; Cohen GM; Melino G. “Caspase cleavage of Itch in chronic lymphocytic leukemia cells”. Biochem Biophys Res Commun, 2009 Feb 13.

Gene Name :

ITCH

Protein Name :

E3 ubiquitin-protein ligase Itchy homolog

Gene Full Name :

itchy E3 ubiquitin protein ligase

Synonyms :

AIF4 antibody AIP4 antibody Atrophin 1 interacting protein 4 antibody Atrophin-1-interacting protein 4 antibody dJ468O1.1 antibody dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) antibody dJ468O1.1 atrophin 1 interacting protein 4 AIP4 antibody E3 ubiquitin protein ligase Itchy homolog antibody E3 ubiquitin-protein ligase Itchy homolog antibody EC 6.3.2 antibody Itch antibody ITCH_HUMAN antibody Itchy E3 ubiquitin protein ligase antibody Itchy E3 ubiquitin protein ligase homolog antibody Itchy E3 ubiquitin protein ligase homolog mouse antibody Itchy E3 ubiquitin protein ligase, mouse, homolog of antibody itchy homolog E3 ubiquitin protein ligase antibody Itchy mouse homolog E3 ubiquitin protein ligase antibody NAPP1 antibody NFE2 associated polypeptide 1 antibody NFE2-associated polypeptide 1 antibody Ubiquitin protein ligase ITCH antibody

Uniprot ID :

Q96J02

more info or order :

Boster Immunoleader product webpage