Boster Immunoleader

antibody

Anti-c Abl Antibody

PB9468

100 ug/vial

240 USD

polyclonal

rabbit

human, rat

Anti-c Abl Antibody

PB9468

Polyclonal

Rabbit IgG polyclonal antibody for Tyrosine-protein kinase ABL1(ABL1) detection. Tested with WB in Human;Rat.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human c Abl (1020-1049aa ERIASGAITKGVVLDSTEALCLAISRNSEQ), different from the related mouse sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

c Abl is also called as ABL1. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene. Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

1. "Entrez Gene: ABI1 abl-interactor 1". 2. Biesova Z, Piccoli C, Wong WT (Feb 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene 14 (2): 233–41. 3. Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (Jul 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J Biol Chem 273 (22): 13681–92.

ABL1

Tyrosine-protein kinase ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

Abelson Murine Leukemia Viral Oncogene Homolog 1 antibody Abelson murine leukemia viral v abl oncogene homolog 1 antibody Abelson tyrosine protein kinase 1 antibody Abl 1 antibody ABL antibody Abl protein antibody ABL proto oncogene 1 non receptor tyrosine kinase antibody Abl1 antibody ABL1_HUMAN antibody bcr/abl antibody Bcr/c abl oncogene protein antibody c abl oncogene 1 non receptor tyrosine kinase antibody c abl oncogene 1 receptor tyrosine kinase antibody JTK 7 antibody JTK7 antibody p150 antibody Proto oncogene tyrosine protein kinase ABL1 antibody Proto-oncogene c-Abl antibody Transformation gene oncogene ABL antibody Tyrosine-protein kinase ABL1 antibody v abl Abelson murine leukemia viral oncogene homolog 1 antibody v abl antibody

P00519