Boster Immunoleader

antibody

Anti-TAB1 Antibody

PB9445

100 ug/vial

240 USD

polyclonal

rabbit

human, rat

Anti-TAB1 Antibody

PB9445

Polyclonal

Rabbit IgG polyclonal antibody for TGF-beta-activated kinase 1/MAP3K7-binding protein 1(TAB1) detection. Tested with WB in Human;Rat.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

WB: The detection limit for TAB1 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human TAB1 (78-108aa NFVAQRLSAELLLGQLNAEHAEADVRRVLLQ), different from the related mouse sequence by two amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, also called TAB1, is an enzyme that in humans is encoded by the MAP3K7IP1 gene. It is mapped to 22q13.1. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways. This protein can interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. TAB1 also can activate the kinase activity of TAK1 by direct interaction, and it may be an important signaling intermediate between TGFB receptors and TAK1. What's more, TAB1 plays an important role in skin homeostasis, wound repair, and oncogenesis.

1. "Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1" 2. Sakurai H, Miyoshi H, Toriumi W, Sugita T (May 1999). "Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation". J Biol Chem274 (15): 10641–8. 3. Shibuya, H., Yamaguchi, K., Shirakabe, K., Tonegawa, A., Gotoh, Y., Ueno, N., Irie, K., Nishida, E., Matsumoto, K. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 272: 1179-1182, 1996.

TAB1

TGF-beta-activated kinase 1/MAP3K7-binding protein 1

TGF-beta activated kinase 1/MAP3K7 binding protein 1

2310012M03Rik antibody 3'-Tab1 antibody MAP3K7IP 1 antibody MAP3K7IP1 antibody MGC57664 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody TAB 1 antibody TAB1 antibody TAK1 binding protein 1 antibody TAK1-binding protein 1 antibody TGF beta activated kinase 1 binding protein 1 antibody TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody TGF-beta-activated kinase 1-binding protein 1 antibody Transforming growth factor beta activated kinase binding protein 1 antibody

Q15750