Anti-SDHA Antibody | Boster Immunoleader PB9433 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-SDHA Antibody

catalog :

PB9433

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-SDHA Antibody

Catalog Number :

PB9433

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial(SDHA) detection. Tested with WB in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human SDHA recombinant protein (Position: S44-L380). Human SDHA shares 98.2% and 97.6% amino acid (aa) sequence identity with mouse and rat SDHA, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Complex II of the mitochondrial respiratory chain, also known as succinate dehydrogenase or succinate:ubiquinone oxidoreductase, consists of 4 nuclear-encoded polypeptides, these are the flavoprotein subunit (SDHA), the iron sulfur protein subunit (SDHB), and the integral membrane protein subunits SDHC and SDHD. SDHA is an acronym for succinate dehydrogenase complex subunit A. The succinate dehydrogenase (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). The SDHA subunit is connected to the SDHB subunit on the hydrophilic, catalytic end of the complex, and weighs 72.7 kDA. Mutations in the SDHA subunit have a distinct pathology from mutations in the SDHB/SDHC/SDHD subunits; it is the only subunit to never have shown tumor suppressor behaviour. Heterozygous carriers of an SDHA mutation do not develop paragangliomas as has been seen for mutations in the other subunits. This appears to be due to the expression of two similar SDHA genes (Types I and II) in the paraganglia system.

Reference :

1. Briere, JJ et al. 2005. Human Molecular Genetics. Vol. 14 pg. 3263-3269.

Gene Name :

SDHA

Protein Name :

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene Full Name :

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Synonyms :

MD1GG antibody DHSA_HUMAN antibody Flavoprotein subunit of complex II antibody FP antibody PGL5 antibody SDH 2 antibody SDH1 antibody SDH2 antibody SDHA antibody SDHF antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial antibody Succinate dehydrogenase complex flavoprotein subunit antibody Succinate dehydrogenase complex flavoprotein subunit precursor antibody Succinate dehydrogenase complex subunit A antibody Succinate dehydrogenase complex subunit A flavoprotein antibody

Uniprot ID :

P31040

more info or order :

Boster Immunoleader product webpage