Anti-ITPR3 Antibody | Boster Immunoleader PB9428 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-ITPR3 Antibody

catalog :

PB9428

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-ITPR3 Antibody

Catalog Number :

PB9428

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 3(ITPR3) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for ITPR3 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human ITPR3 (70-95aa QYWKAKQTKQDKEKIADVVLLQKLQH), identical to the related mouse and rat sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

Reference :

1. "Entrez Gene: inositol 1". 2. Chaudhari N, Roper SD (August 2010)."The cell biology of taste". J. Cell Biol.190 (3): 285–96. 3. Yamamoto-Hino M, Sugiyama T, Hikichi K et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors".Recept. Channels 2 (1): 9–22.

Gene Name :

ITPR3

Protein Name :

Inositol 1,4,5-trisphosphate receptor type 3

Gene Full Name :

inositol 1,4,5-trisphosphate receptor, type 3

Synonyms :

4 antibody 5-trisphosphate receptor antibody 5-trisphosphate receptor type 3 antibody FLJ36205 antibody Inositol 1 antibody Inositol 1,4,5 trisphosphate receptor type 3 antibody InsP3R3 antibody IP3 receptor antibody IP3 receptor isoform 3 antibody IP3R 3 antibody IP3R antibody IP3R3 antibody ITPR 3 antibody ITPR3 antibody ITPR3_HUMAN antibody Type 3 inositol 1 antibody Type 3 inositol 1,4,5 trisphosphate receptor antibody Type 3 InsP3 receptor antibody

Uniprot ID :

Q14573

more info or order :

Boster Immunoleader product webpage