Boster Immunoleader

antibody

Anti-SOCS2 Antibody

PB9400

100 ug/vial

240 USD

polyclonal

rabbit

human, rat

Anti-SOCS2 Antibody

PB9400

Polyclonal

Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 2(SOCS2) detection. Tested with WB in Human;Rat.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

WB: The detection limit for SOCS2 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human SOCS2 recombinant protein (Position: R96-V198). Human SOCS2 shares 96.1% and 95.1% amino acid (aa) sequence identity with mouse and rat SOCS2, respectively.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. By cytogenetic and radiation hybrid mapping, Yandava et al. (1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

1. "Entrez Gene: SOCS2 suppressor of cytokine signaling 2". 2. Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. 3. Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, Davey HW, Nicola NA, Hilton DJ, Alexander WS (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Mol. Endocrinol. 16 (6): 1394–406. 4. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun 239 (2): 439–46. 5. Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (Sep 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun 237 (1): 79–83.

SOCS2

Suppressor of cytokine signaling 2

suppressor of cytokine signaling 2

CIS 2 antibody CIS-2 antibody CIS2 antibody Cish 2 antibody Cish2 antibody Cytokine inducible SH2 protein 2 antibody Cytokine-inducible SH2 protein 2 antibody SOCS 2 antibody SOCS-2 antibody Socs2 antibody SOCS2_HUMAN antibody SSI 2 antibody SSI-2 antibody SSI2 antibody STAT induced STAT inhibitor 2 antibody STAT-induced STAT inhibitor 2 antibody STATI 2 antibody STATI2 antibody Suppressor of cytokine signaling 2 antibody

O14508