Boster Immunoleader

antibody

Anti-PTEN Antibody

PB9385

100 ug/vial

240 USD

polyclonal

rabbit

human, rat

Anti-PTEN Antibody

PB9385

Polyclonal

Rabbit IgG polyclonal antibody for Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN(PTEN) detection. Tested with WB in Human;Rat.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: rat Predicted to work with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Human

WB: The detection limit for PTEN is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human PTEN recombinant protein (Position: E91-V403). Human PTEN shares 99.7% amino acid (aa) sequence identity with mouse PTEN.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

PTEN is also known as BZS, DEC, CWS1, GLM2, MHAM, TEP1, PTEN1. It is mapped to 10q23.3. This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. The PTEN structure reveals a phosphatase domain that is similar to protein phosphatases but also has an enlarged active site important for the accommodation of the phosphoinositide substrate.

1. Lee, J.-O., Yang, H., Georgescu, M.-M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J. E., Pandolfi, P., Pavletich, N. P. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99: 323-334, 1999.

PTEN

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

phosphatase and tensin homolog

10q23del antibody Bannayan Zonana syndrome antibody BZS antibody DEC antibody GLM2 antibody ITGA 2 antibody MGC11227 antibody MHAM antibody MMAC 1 antibody MMAC1 antibody MMAC1 phosphatase and tensin homolog deleted on chromosome 10 antibody Multiple hamartoma (Cowden syndrome) antibody Mutated in multiple advanced cancers 1 antibody Mutated in Mutiple Advanced Cancers 1 antibody Phosphatase and Tensin Homolog antibody Phosphatase and tensin like protein antibody Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN antibody Phosphatidylinositol 345 trisphosphate 3 phosphatase antibody Phosphatidylinositol-3,4,5-trisphosphate 3 phosphatase and dual-specificity protein phosphatase PTEN antibody Platelet antigen BR antibody PTEN 1 antibody Pten antibody PTEN_HUMAN antibody PTEN1 antibody Tensin homolog antibody TEP 1 antibody TEP1 antibody VLA 2 Receptor Alpha Subunit antibody

P60484