Anti-SIRT7 Antibody | Boster Immunoleader PB9358 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-SIRT7 Antibody

catalog :

PB9358

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-SIRT7 Antibody

Catalog Number :

PB9358

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for NAD-dependent protein deacetylase sirtuin-7(SIRT7) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Mouse, Rat; Predicted Species: Human

Notes :

WB: The detection limit for SIRT7 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human SIRT7 recombinant protein (Position: R8-G350). Human SIRT7 shares 96% and 95% amino acid (aa) sequence identity with mouse and rat SIRT7, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

SIRT7 is also known as SIR2L7. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Reference :

1. Altered sirtuin expression is associated with node-positive breast cancer.Ashraf N, et al. Br J Cancer, 2006 Oct 23. 2. Molecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer.Paredes S, et al. Clin Cancer Res, 2014 Apr 1. 3. Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis.Tsai YC, et al. Mol Cell Proteomics, 2014 Jan.

Gene Name :

SIRT7

Protein Name :

NAD-dependent protein deacetylase sirtuin-7

Gene Full Name :

sirtuin 7

Synonyms :

NAD dependent deacetylase sirtuin 7 antibody NAD dependent protein deacetylase sirtuin 7 antibody NAD-dependent deacetylase sirtuin-7 antibody Regulatory protein SIR2 homolog 7 antibody Silent mating type information regulation 2 homolog antibody Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody SIR2 L7 antibody SIR2 like protein 7 antibody Sir2 related protein type 7 antibody SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 antibody SIR2-like protein 7 antibody SIR2L 7 antibody SIR2L7 antibody SIRT 7 antibody SIRT7 antibody SIRT7_HUMAN antibody Sirtuin 7 antibody Sirtuin type 7 antibody Sirtuin7 antibody

Uniprot ID :

Q9NRC8

more info or order :

Boster Immunoleader product webpage