Boster Immunoleader

antibody

Anti-SIRT6 Antibody

PB9357

100 ug/vial

240 USD

polyclonal

rabbit

human, mouse

western blot, immunohistochemistry - paraffin section

Anti-SIRT6 Antibody

PB9357

Polyclonal

Rabbit IgG polyclonal antibody for NAD-dependent protein deacetylase sirtuin-6(SIRT6) detection. Tested with WB, IHC-P in Human;Mouse.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse

WB: The detection limit for SIRT6 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human SIRT6 recombinant protein (Position: D14-E180). Human SIRT6 shares 95% amino acid (aa) sequence identity with mouse SIRT6.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

SIRT6 is also known as SIR2L6. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

1. Kugel S, et al. Chromatin and beyond: the multitasking roles for SIRT6. Trends Biochem Sci, 2014 Feb. 2. Takasaka N, et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol, 2014 Feb 1. 3. Zhang ZG, et al. Sirt6 suppresses hepatocellular carcinoma cell growth via inhibiting the extracellular signal regulated kinase signaling pathway. Mol Med Rep, 2014 Mar.

SIRT6

NAD-dependent protein deacetylase sirtuin-6

sirtuin 6

2810449N18Rik antibody AI043036 antibody Mono ADP ribosyltransferase sirtuin 6 antibody Mono-ADP-ribosyltransferase sirtuin-6 antibody NAD-dependent deacetylase sirtuin-6 antibody NAD-dependent protein deacetylase sirtuin-6 antibody Regulatory proteinSIR2 homolog antibody SIR2 like 6 antibody SIR2 like protein 6 antibody Sir2 related protein type 6 antibody SIR2-like protein 6 antibody SIR2L6 antibody SIRT 6 antibody SIRT6 antibody SIRT6_HUMAN antibody Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody Sirtuin 6 antibody Sirtuin type 6 antibody Sirtuin6 antibody

Q8N6T7