Anti-TPA Antibody | Boster Immunoleader PB9345 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-TPA Antibody

catalog :

PB9345

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-TPA Antibody

Catalog Number :

PB9345

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Tissue-type plasminogen activator(PLAT) detection. Tested with WB in Human;Mouse.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse

Notes :

WB: The detection limit for TPA is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human TPA recombinant protein (Position: H366-P562). Human TPA shares 83% and 84% amino acid (aa) sequence identity with mouse and rat TPA, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

PLAT is also known as tPA. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Reference :

1. Marsh EB, et al. Serum creatinine may indicate risk of symptomatic intracranial hemorrhage after intravenous tissue plasminogen activator (IV tPA). Medicine (Baltimore), 2013 Nov. 2. Valle-Garay E, et al. tPA Alu (I/D) polymorphism associates with bacterial osteomyelitis. J Infect Dis, 2013 Jul 15.

Gene Name :

PLAT

Protein Name :

Tissue-type plasminogen activator

Gene Full Name :

plasminogen activator, tissue

Synonyms :

Alteplase antibody DKFZp686I03148 antibody Plasminogen activator tissue antibody Plasminogen activator tissue type antibody Plasminogen Activator Tissue Type Isoform 1 Preproprotein antibody PLAT antibody Reteplase antibody t PA antibody T Plasminogen Activator antibody t-PA antibody T-plasminogen activator antibody Tissue plasminogen activator (t PA) antibody Tissue type plasminogen activator antibody Tissue-type plasminogen activator chain B antibody TPA antibody TPA_HUMAN antibody TPA1 antibody

Uniprot ID :

P00750

more info or order :

Boster Immunoleader product webpage