Anti-APPBP1 Antibody | Boster Immunoleader PB9339 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-APPBP1 Antibody

catalog :

PB9339

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-APPBP1 Antibody

Catalog Number :

PB9339

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for NEDD8-activating enzyme E1 regulatory subunit(NAE1) detection. Tested with WB in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for APPBP1 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human APPBP1 recombinant protein (Position: E181-L534). Human APPBP1 shares 98% amino acid (aa) sequence identity with mouse APPBP1.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

NAE1 is also known as APPBP1. The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Reference :

1. Hong BH, et al. Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. Neuroreport, 2012 Jan 25. 2. Joo Y, et al. Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells. PLoS One, 2010 Dec 2. 3. Zhong HJ, et al. A metal-based inhibitor of NEDD8-activating enzyme. PLoS One, 2012.

Gene Name :

NAE1

Protein Name :

NEDD8-activating enzyme E1 regulatory subunit

Gene Full Name :

NEDD8 activating enzyme E1 subunit 1

Synonyms :

59 kDa antibody A 116A10.1 antibody Amyloid beta precursor protein binding protein 1 59kD antibody Amyloid beta precursor protein binding protein 1 59kDa antibody Amyloid beta precursor protein binding protein 1 antibody Amyloid beta precursor protein-binding protein 1 antibody Amyloid protein binding protein 1 antibody Amyloid protein-binding protein 1 antibody APP BP1 antibody APP-BP1 antibody APPBP 1 antibody HPP 1 antibody HPP1 antibody NAE 1 antibody NAE1 antibody NEDD8 activating enzyme E1 regulatory subunit antibody NEDD8 activating enzyme E1 subunit 1 antibody NEDD8 activating enzyme E1 subunit antibody NEDD8-activating enzyme E1 regulatory subunit antibody Proto oncogene protein 1 antibody Proto-oncogene protein 1 antibody Protooncogene protein 1 antibody ula 1 antibody ULA1_HUMAN antibody

Uniprot ID :

Q13564

more info or order :

Boster Immunoleader product webpage