Anti-SHBG Antibody | Boster Immunoleader PB9326 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-SHBG Antibody

catalog :

PB9326

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-SHBG Antibody

Catalog Number :

PB9326

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Sex hormone-binding globulin(SHBG) detection. Tested with WB in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

WB: The detection limit for SHBG is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human SHBG recombinant protein (Position: L30-A210). Human SHBG shares 72% amino acid (aa) sequence identity with both mouse and rat SHBG.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones,androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.

Reference :

1. Hammond GL (2011). "Diverse Roles for Sex Hormone-Binding Globulin in Reproduction". Biology of Reproduction 85(3): 431–441. 2. Selva, D. M., Hogeveen, K. N., Innis, S. M., Hammond, G. L. Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J. Clin. Invest. 117: 3979-3987, 2007. 3. Simó R, Barbosa-Desongles A, Hernandez C, Selva DM (November 2012). "IL1β down-regulation of sex hormone-binding globulin production by decreasing HNF-4α via MEK-1/2 and JNK MAPK pathways". Mol. Endocrinol. 26 (11): 1917–27.

Gene Name :

SHBG

Protein Name :

Sex hormone-binding globulin

Gene Full Name :

sex hormone-binding globulin

Synonyms :

ABP antibody Androgen binding protein antibody SBP antibody Sex hormone-binding globulin antibody Sex steroid binding protein antibody Sex steroid-binding protein antibody SHBG antibody SHBG_HUMAN antibody TeBG antibody Testis specific androgen binding protein antibody Testis-specific androgen-binding protein antibody Testosterone binding beta globulin antibody Testosterone estradiol binding globulin antibody Testosterone estrogen binding globulin antibody Testosterone-estradiol-binding globulin antibody Testosterone-estrogen-binding globulin antibody

Uniprot ID :

P04278

more info or order :

Boster Immunoleader product webpage