Anti-Pin1 Antibody | Boster Immunoleader PB9316 product information

product summary

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company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Pin1 Antibody

catalog :

PB9316

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Pin1 Antibody

Catalog Number :

PB9316

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(PIN1) detection. Tested with WB in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for Pin1 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human Pin1 recombinant protein (Position: M1-E163). Human Pin1 shares 95% amino acid (aa) sequence identity with mouse Pin1.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role as a post phospho PIN1rol in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

Reference :

1. Liou, Y.-C., Ryo, A., Huang, H.-K., Lu, P.-J., Bronson, R., Fujimori, F., Uchida, T., Hunter, T., Lu, K. P. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc. Nat. Acad. Sci. 99: 1335-1340, 2002. 2. Lu, KP; Finn G; Lee TH; Nicholson LK (Oct 2007). "Prolyl cis-trans isomerization as a molecular timer".Nat. Chem. Biol. (United States) 3 (10): 619–29.

Gene Name :

PIN1

Protein Name :

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Gene Full Name :

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Synonyms :

DOD antibody DODO, Drosophila, homolog of antibody FLJ40239 antibody FLJ77628 antibody MGC10717 antibody NIMA interacting 1 antibody Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody Peptidyl prolyl cis/trans isomerase NIMA interacting antibody Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody Peptidyl-prolyl cis-trans isomerase pin1 antibody Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody Pin 1 antibody Pin1 antibody PIN1_HUMAN antibody PPIase Pin1 antibody Prolyl isomerase antibody Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody Protein NIMA interacting 1 antibody Rotamase Pin1 antibody UBL 5 antibody UBL5 antibody

Uniprot ID :

Q13526

more info or order :

Boster Immunoleader product webpage