Boster Immunoleader

antibody

Anti-P2RX4 Antibody

PB9304

100 ug/vial

240 USD

polyclonal

rabbit

Anti-P2RX4 Antibody

PB9304

Polyclonal

Rabbit IgG polyclonal antibody for P2X purinoceptor 4(P2RX4) detection. Tested with WB in Human.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

WB: The detection limit for P2RX4 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human P2RX4 recombinant protein (Position: N262-Q388). Human P2RX4 shares 91% and 90% amino acid (aa) sequence identity with mouse and rat P2RX4, respectively.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Purinoceptor P2X4, also called P2X4R is a protein that in humans is encoded by the P2RX4 gene. This gene belongs to the family of purinoceptors for ATP. P2RX4 was mapped to 12q24.32 by fluorescence in situ hybridization. P2RX4 is a receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. P2X4 receptor in hyperactive microglia is necessary for tactile allodynia after nerve injury and is sufficient to produce tactile allodynia in normal animals. P2X4 recetors have beeb implicated in the regulation of cardiac function, ATP-mediated cell death, synaptic strengthening, and activating of the inflammasome in response to injury.

1. Adrian, K., Bernhard, M. K., Breitinger, H.-G., Ogilvie, A. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. Biochim. Biophys. Acta 1492: 127-138, 2000. 2. Kawate, T., Michel, J. C., Birdsong, W. T., Gouaux, E. Crystal structure of the ATP-gated P2X4 ion channel in the closed state. Nature 460: 592-598, 2009. 3. Wilson, S. G., Adam, G., Langdown, M., Reneland, R., Braun, A., Andrew, T., Surdulescu, G. L., Norberg, M., Dudbridge, F., Reed, P. W., Sambrook, P. N., Kleyn, P. W., Spector, T. D. Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort. Europ. J. Hum. Genet. 14: 340-348, 2006. 4. Yamamoto, K., Sokabe, T., Matsumoto, T., Yoshimura, K., Shibata, M., Ohura, N., Fukuda, T., Sato, T., Sekine, K., Kato, S., Isshiki, M., Fujita, T., Kobayashi, M., Kawamura, K., Masuda, H., Kamiya, A., Ando, J. Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nature Med. 12: 133-137, 2006.

P2RX4

P2X purinoceptor 4

purinergic receptor P2X, ligand gated ion channel, 4

AI504491 antibody ATP gated cation channel protein antibody ATP receptor antibody AW555605 antibody D5Ertd444e antibody MGC143034 antibody OTTMUSP00000023741 antibody OTTMUSP00000023745 antibody OTTMUSP00000023746 antibody OTTMUSP00000023747 antibody p2rx4 antibody P2RX4_HUMAN antibody P2X purinoceptor 4 antibody P2X receptor subunit 4 antibody P2X4 antibody P2X4R antibody Purinergic receptor antibody Purinergic receptor P2X ligand gated ion channel 4 antibody Purinergic receptor P2X4 antibody Purinoceptor P2X4 antibody

Q99571