Anti-LKB1 Antibody | Boster Immunoleader PB9270 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-LKB1 Antibody

catalog :

PB9270

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-LKB1 Antibody

Catalog Number :

PB9270

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase STK11(STK11) detection. Tested with WB in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

WB: The detection limit for LKB1 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human LKB1 recombinant protein (Position: K62-C430). Human LKB1 shares 89% amino acid (aa) sequence identity with both mouse and rat LKB1.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor. STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis. It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. The STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction.

Reference :

1. Brown KA, McInnes KJ, Takagi K, Ono K, Hunger NI, Wang L, Sasano H, Simpson ER (November 2011). "LKB1 expression is inhibited by estradiol-17β in MCF-7 cells". J. Steroid Biochem. Mol. Biol. 127 (3-5): 439–43. 2. Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M (January 1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase".

Gene Name :

STK11

Protein Name :

Serine/threonine-protein kinase STK11

Gene Full Name :

serine/threonine kinase 11

Synonyms :

hLKB1 antibody Liver kinase B1 antibody LKB 1 antibody LKB1 antibody NY REN 19 antigen antibody Peutz Jeghers syndrome antibody PJS antibody Polarization related protein LKB1 antibody Renal carcinoma antigen NY-REN-19 antibody Serine/Threonine Kinase 11 antibody Serine/threonine protein kinase 11 antibody Serine/threonine protein kinase LKB1 antibody Serine/threonine protein kinase STK11 antibody Serine/threonine-protein kinase 11 antibody Serine/threonine-protein kinase LKB1 antibody Serine/threonine-protein kinase XEEK1 antibody STK 11 antibody STK11 antibody STK11_HUMAN antibody

Uniprot ID :

Q15831

more info or order :

Boster Immunoleader product webpage