Anti-KCNH2 Antibody | Boster Immunoleader PB9257 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-KCNH2 Antibody

catalog :

PB9257

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-KCNH2 Antibody

Catalog Number :

PB9257

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Potassium voltage-gated channel subfamily H member 2(KCNH2) detection. Tested with WB in Human;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Notes :

WB: The detection limit for KCNH2 is approximately 0.2ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human KCNH2 recombinant protein (Position: L856-S1159). Human KCNH2 shares 92% amino acid (aa) sequence identity with both mouse and rat KCNH2.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

KCNH2, also known as HERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K+) ions out of the muscle cells of the heart (cardiac myocytes), and this current is critical in correctly timing the return to the resting state (repolarization) of the cell membrane during the cardiac action potential. What’s more, KCNH2 channels show gating properties consistent with many of the outwardly rectifying potassium channels, but they also have an inactivation mechanism that attenuates efflux during depolarization.

Reference :

1. Gianulis, E. C., Trudeau, M. C. Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-a-go-go-related gene potassium channels. J. Biol. Chem. 286: 22160-22169, 2011. 2. Hedley PL; Jorgensen P; Schlamowitz S; Wangari, Romilda et al. (2009). "The genetic basis of long QT and short QT syndromes: a mutation update". Human Mutation 30 (11): 1486–511. 3. Thomas, P. J., Qu, B.-H., Pedersen, P. L. Defective protein folding as a basis of human disease. Trends Biochem. Sci. 20: 456-459, 1995.

Gene Name :

KCNH2

Protein Name :

Potassium voltage-gated channel subfamily H member 2

Gene Full Name :

potassium voltage-gated channel, subfamily H (eag-related), member 2

Synonyms :

eag homolog antibody Eag-related protein 1 antibody ERG antibody ERG-1 antibody ERG1 antibody Ether a go go related potassium channel protein antibody Ether-a-go-go-related gene potassium channel 1 antibody Ether-a-go-go-related protein 1 antibody H ERG antibody H-ERG antibody HERG 1 antibody HERG antibody hERG-1 antibody HERG1 antibody KCNH2 antibody KCNH2_HUMAN antibody Kv11.1 antibody LQT 2 antibody LQT2 antibody Potassium channel HERG antibody Potassium voltage gated channel subfamily H (eag related) member 2 antibody Potassium voltage-gated channel subfamily H member 2 antibody SQT1 antibody Voltage gated potassium channel, subfamily H, member 2 antibody Voltage-gated potassium channel subunit Kv11.1 antibody Voltagegated potassium channel, subfamily H, member 2 antibody

Uniprot ID :

Q12809

more info or order :

Boster Immunoleader product webpage