Anti-KCNMA1 Antibody | Boster Immunoleader PB9227 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-KCNMA1 Antibody

catalog :

PB9227

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

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product information

Product Name :

Anti-KCNMA1 Antibody

Catalog Number :

PB9227

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Calcium-activated potassium channel subunit alpha-1(KCNMA1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat; Predicted Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for KCNMA1 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human KCNMA1 recombinant protein (Position: K124-Q467). Human KCNMA1 shares 99% amino acid (aa) sequence identity with both mouse and rat KCNMA1.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

Calcium-activated potassium channel subunit alpha-1 also known as KCa1.1, or BK channel for short, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by their large conductance of potassium ions (K+) through cell membranes. This gene is located on 10q22.3. BK channels are activated (opened) by changes in membrane electrical potential and/or by increases in concentration of intracellular calcium ion (Ca2+). It is essential for the regulation of several key physiological processes including smooth muscle tone and neuronal excitability. BK channels also contribute to the behavioral effects of ethanol in the worm C. elegans under high concentrations (> 100 mM, or approximately 0.50% BAC).It remains to be determined if BK channels contribute to intoxication in humans.

Reference :

1. "Entrez Gene: KCNMA1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1" 2. Miller C (2000). "An overview of the potassium channel family". Genome Biol. 1 (4): reviews0004.1–reviews0004.5. 3. Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R (July 2010). "Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution". Science 329 (5988): 182–6. Bibcode:2010Sci. 329. 182Y.

Gene Name :

KCNMA1

Protein Name :

Calcium-activated potassium channel subunit alpha-1

Gene Full Name :

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Synonyms :

subfamily M subunit alpha-1 antibody bA205K10.1 antibody BK channel antibody BKCA alpha antibody BKCA alpha subunit antibody BKTM antibody Calcium activated potassium channel subfamily M subunit alpha 1 antibody Calcium activated potassium channel subunit alpha 1 antibody Calcium-activated potassium channel antibody Calcium-activated potassium channel subunit alpha-1 antibody DKFZp686K1437 antibody Drosophila slowpoke like antibody hSlo antibody K(VCA)alpha antibody KCa1.1 antibody KCMA1_HUMAN antibody KCNMA 1 antibody KCNMA antibody KCNMA1 antibody Large conductance calcium activated potassium channel subfamily M alpha member 1 antibody Maxi K antibody Maxi K channel antibody Maxi Potassium channel alpha antibody MaxiK antibody MGC71881 antibody OTTHUMP00000060198 antibody OTTHUMP00000064154 antibody OTTHUMP00000064155 antibody OTTHUMP00000064156 antibody OTTHUMP00000064157 antibody OTTHUMP00000064158 antibody OTTHUMP00000064159 antibody OTTHUMP00000064160 antibody OTTHUMP00000064161 antibody OTTHUMP00000064162 antibody OTTHUMP00000064164 antibody OTTHUMP00000064165 antibody Potassium large conductance calcium activated channel subfamily M alpha member 1 antibody SAKCA antibody Slo 1 antibody SLO alpha antibody SLO antibody Slo homolog antibody Slo-alpha antibody Slo1 antibody Slowpoke homolog antibody Stretch activated Kca channel antibody

Uniprot ID :

Q12791

more info or order :

Boster Immunoleader product webpage