Boster Immunoleader

antibody

Anti-IP3 receptor Antibody

PB9225

100 ug/vial

240 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-IP3 receptor Antibody

PB9225

Polyclonal

Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse, rat

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

WB: The detection limit for IP3 receptor is approximately 0.2ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human IP3 receptor recombinant protein (Position: A2411-A2758). Human IP3 receptor shares 98% and 97% amino acid (aa) sequences identity with mouse and rat IP3 receptor, respectively.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate(IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.

1. "Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1" 2. Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., Minowa, O., Kuno, J., Sakakibara, S., Yamada, M., Yoneshima, H., Miyawaki, A, Fukuichi, T., Furuichi, T., Okano, H., Mikoshiba, K., Noda, T. Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-triphosphate receptor. Nature 379: 168-171, 1996.

ITPR1

Inositol 1,4,5-trisphosphate receptor type 1

inositol 1,4,5-trisphosphate receptor, type 1

4 antibody 5-trisphosphate receptor antibody 5-trisphosphate receptor type 1 antibody DKFZp313E1334 antibody DKFZp313N1434 antibody inositol 1 4 5 triphosphate receptor type 1 antibody Inositol 1 4 5 trisphosphate Receptor Type 1 antibody Inositol 1 antibody Inositol 145-trisphosphate Receptor Type 1 antibody InsP3R1 antibody IP3 antibody IP3 receptor antibody IP3 receptor isoform 1 antibody IP3R 1 antibody IP3R antibody IP3R1 antibody ITPR 1 antibody Itpr1 antibody ITPR1_HUMAN antibody SCA15 antibody SCA16 antibody SCA29 antibody Type 1 inositol 1 4 5 trisphosphate receptor antibody Type 1 inositol 1 antibody Type 1 InsP3 receptor antibody

Q14643