Anti-IRS2 Antibody | Boster Immunoleader PB9224 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-IRS2 Antibody

catalog :

PB9224

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-IRS2 Antibody

Catalog Number :

PB9224

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Insulin receptor substrate 2(IRS2) detection. Tested with WB in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

WB: The detection limit for IRS2 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human IRS2 recombinant protein (Position: D16-V200). Human IRS2 shares 88% amino acid (aa) sequence identity with mouse IRS2.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Insulin receptor substrate 2 (IRS2) is a protein that in humans is encoded by the IRS2 gene. It is mapped to 13q34. This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. IRS2 is expressed in many cells, it may be essential for signaling by several receptor systems.

Reference :

1. Sun, X. J., Wang, L.-M., Zhang, Y., Yenush, L., Myers, M. G., Jr., Glasheen, E., Lane, W. S., Pierce, J. H., White, M. F. Role of IRS-2 in insulin and cytokine signalling. Nature 377: 173-177, 1995. 2. Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T (Oct 1997). "14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain". J Biol Chem 272 (40): 25267–74. 3. "Entrez Gene: IRS2 insulin receptor substrate 2

Gene Name :

IRS2

Protein Name :

Insulin receptor substrate 2

Gene Full Name :

insulin receptor substrate 2

Synonyms :

Insulin receptor substrate 2 antibody IRS 2 antibody IRS-2 antibody Irs2 antibody IRS2_HUMAN antibody

Uniprot ID :

Q9Y4H2

more info or order :

Boster Immunoleader product webpage