Boster Immunoleader

antibody

Anti-IKK beta Antibody

PB9221

100 ug/vial

240 USD

polyclonal

rabbit

western blot, immunohistochemistry - paraffin section

Anti-IKK beta Antibody

PB9221

Polyclonal

Rabbit IgG polyclonal antibody for Inhibitor of nuclear factor kappa-B kinase subunit beta(IKBKB) detection. Tested with WB, IHC-P in Human.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Concentration: 0.5-1μg/ml; Tested Species: Human

WB: The detection limit for IKK beta is approximately 0.2ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human IKK beta recombinant protein (Position: E398-S756). Human IKK beta shares 91% and 90% amino acid (aa) sequences identity with mouse and rat IKK beta, respectively.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

IKBKB(Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Kinase of, Beta), also known as IKKB or NFKBIKB, is a protein that in humans is encoded by the IKBKB gene. This gene is mapped to chromosome 8p12-p11 by FISH. It is found that mutations in IKK2 had a more pronounced effect upon NFKB activation than did comparable mutations in IKK1. The activity of various antiinflammatory agents on the IKK complex has been texted, it has been found that aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo by binding to IKK-beta to reduce ATP binding.

1. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., Mann, M., Manning, A., Rao, A. IKK-1 and IKK-2: cytokine-activated I-kappa-B kinases essential for NF-kappa-B activation. Science 278: 860-866, 1997. 2. Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., Donner, D. B. NF-kappa-B activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85, 1999. 3. Yin, M.-J., Yamamoto, Y., Gaynor, R. B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I-kappa-B kinase-beta. Nature 396: 77-80, 1998.

IKBKB

Inhibitor of nuclear factor kappa-B kinase subunit beta

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

I kappa B kinase 2 antibody I kappa B kinase beta antibody I-kappa-B kinase 2 antibody I-kappa-B-kinase beta antibody IkBKB antibody IKK 2 antibody IKK B antibody IKK beta antibody IKK-B antibody IKK-beta antibody IKK2 antibody IKKB antibody IKKB_HUMAN antibody IMD15 antibody Inhibitor of kappa light chain gene enhancer in B cells antibody Inhibitor of kappa light polypeptide gene enhancer in B cells antibody Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta antibody Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta antibody Inhibitor of nuclear factor kappa B kinase beta subunit antibody Inhibitor of nuclear factor kappa B kinase subunit beta antibody Inhibitor of nuclear factor kappa-B kinase subunit beta antibody MGC131801 antibody NFKBIKB antibody Nuclear factor NF kappa B inhibitor kinase beta antibody Nuclear factor NF-kappa-B inhibitor kinase beta antibody Nuclear factor of kappa light chain gene enhancer in B cells inhibitor antibody

O14920