Anti-HCN1 Antibody | Boster Immunoleader PB9210 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-HCN1 Antibody

catalog :

PB9210

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-HCN1 Antibody

Catalog Number :

PB9210

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) detection. Tested with WB in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for HCN1 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human HCN1 recombinant protein (Position: E618-L890). Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse and rat HCN1.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. It may mediates responses to sour stimuli.

Reference :

1. Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc Natl Acad Sci U S A 94 (26): 14815–20. 2. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–29. 3. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455–62. 4. "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1

Gene Name :

HCN1

Protein Name :

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Gene Full Name :

hyperpolarization activated cyclic nucleotide-gated potassium channel 1

Synonyms :

BCNG-1 antibody BCNG1 antibody Brain cyclic nucleotide gated channel 1 antibody Brain cyclic nucleotide-gated channel 1 antibody HAC 2 antibody HAC2 antibody HCN1 antibody HCN1_HUMAN antibody Hyperpolarization activated cyclic nucleotide gated potassium channel 1 antibody Potassium channel, voltage-gated, brain, 1 antibody Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1 antibody Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 antibody

Uniprot ID :

O60741

more info or order :

Boster Immunoleader product webpage