Anti-GRIA1 Antibody | Boster Immunoleader PB9204 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-GRIA1 Antibody

catalog :

PB9204

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

more info or order :

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product information

Product Name :

Anti-GRIA1 Antibody

Catalog Number :

PB9204

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Glutamate receptor 1(GRIA1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Notes :

WB: The detection limit for GRIA1 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human GRIA1 recombinant protein (Position: A19-R360). Human GRIA1 shares 98% amino acid (aa) sequence identity with both mouse and rat GRIA1.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

GLUR1, Glutamate receptor 1, is a protein that in humans is encoded by the GLUR1 gene. GLUR1 mRNA is widely expressed in human brain. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.

Reference :

1. Lee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., Wenthold, R. J., Gallagher, M., Huganir, R. L.Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory.Cell 112: 631-643, 2003. 2. McLaughlin, D. P., Cheetham, M. E., Kerwin, R. W.Expression of alternatively-spliced glutamate receptors in human hippocampus.Europ. J. Pharm. 244: 89-92, 1993.

Gene Name :

GRIA1

Protein Name :

Glutamate receptor 1

Gene Full Name :

glutamate receptor, ionotropic, AMPA 1

Synonyms :

GLUR 1 antibody GLUR A antibody AMPA 1 antibody AMPA selective glutamate receptor 1 antibody AMPA-selective glutamate receptor 1 antibody GluA1 antibody GLUH 1 antibody GLUH1 antibody GluR K1 antibody GluR-1 antibody GluR-A antibody GluR-K1 antibody GLUR1 antibody GLURA antibody GluRK1 antibody Glutamate receptor 1 antibody Glutamate receptor ionotropic AMPA 1 antibody Glutamate receptor ionotropic antibody Glutamate receptor, ionotropic, AMPA 1 antibody Gria 1 antibody Gria1 antibody GRIA1_HUMAN antibody HBGR1 antibody MGC133252 antibody OTTHUMP00000160643 antibody OTTHUMP00000165781 antibody OTTHUMP00000224241 antibody OTTHUMP00000224242 antibody OTTHUMP00000224243 antibody

Uniprot ID :

P42261

more info or order :

Boster Immunoleader product webpage