Anti-Estrogen Receptor Antibody | Boster Immunoleader PB9192 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Estrogen Receptor Antibody

catalog :

PB9192

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunohistochemistry - paraffin section

publications citing this reagent :

Fu Y, Zhao Z, Wu Y, Wu K, Xu X, Liu Y, et al. Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure. J Ethnopharmacol. 2012;139:26-33 pubmed publisher

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product information

Product Name :

Anti-Estrogen Receptor Antibody

Catalog Number :

PB9192

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Estrogen receptor(ESR1) detection. Tested with WB, IHC-P in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

WB: The detection limit for Estrogen Receptor is approximately 0.2ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human Estrogen Receptor recombinant protein (Position: F425-V595). Human Estrogen Receptor shares 89% and 88% amino acid (aa) sequences identity with mouse and rat Estrogen Receptor, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

Estrogen receptor alpha (ER-α), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. In humans, ER-α is encoded by the gene ESR1 (Estrogen Receptor 1). It is mapped to 6q25.1. This gene is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, it also play a role in other tissues such as bone.

Reference :

1. "Entrez Gene: ESR1 estrogen receptor 1" 2. Walter P, Green S, Greene G, Krust A, Bornert JM, Jeltsch JM, Staub A, Jensen E, Scrace G, Waterfield M (December 1985). "Cloning of the human estrogen receptor cDNA". Proc. Natl. Acad. Sci. U.S.A. 82 (23): 7889–93. 3. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J (March 1986). "Sequence and expression of human estrogen receptor complementary DNA". Science 231 (4742): 1150–4.

Gene Name :

ESR1

Protein Name :

Estrogen receptor

Gene Full Name :

estrogen receptor 1

Synonyms :

Atherosclerosis, susceptibility to, included antibody DKFZp686N23123 antibody ER Alpha antibody ER antibody ER Beta antibody ER-alpha antibody ER[a] antibody ER[b] antibody ERA antibody ERalpha antibody Erb antibody Erb2 antibody ERbeta antibody ESR 1 antibody ESR antibody ESR BETA antibody ESR1 antibody ESR1_HUMAN antibody ESR2 antibody ESRA antibody ESRB antibody Estr antibody Estra antibody Estradiol Receptor alpha antibody Estradiol Receptor antibody Estradiol Receptor beta antibody ESTRB antibody Estrogen receptor 1 (alpha) antibody Estrogen receptor 1 antibody Estrogen receptor 2 (ER beta) antibody Estrogen Receptor 2 antibody Estrogen receptor 2 ER beta antibody Estrogen receptor alpha antibody Estrogen receptor antibody Estrogen receptor beta 4 antibody Estrogen resistance, included antibody HDL cholesterol, augmented response of, to hormone replacement, included antibody Myocardial infarction, susceptibility to, included antibody NR3A 1 antibody NR3A1 antibody NR3A2 antibody Nuclear receptor subfamily 3 group A member 1 antibody Nuclear receptor subfamily 3 group A member 2 antibody OTTHUMP00000017718 antibody OTTHUMP00000017719 antibody RNESTROR antibody

Uniprot ID :

P03372

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