Anti-gamma Catenin Antibody | Boster Immunoleader PB9185 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-gamma Catenin Antibody

catalog :

PB9185

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-gamma Catenin Antibody

Catalog Number :

PB9185

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Junction plakoglobin(JUP) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P,IHC-F,ICC

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Immunohistochemistry(Frozen Section) :

Concentration: 0.5-1μg/ml; Tested Species: Rat; Predicted Species: Human

Immunocytochemistry :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

WB: The detection limit for gamma Catenin is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human gamma Catenin recombinant protein (Position: M556-A745). Human gamma Catenin shares 98% amino acid (aa) sequence identity with both mouse and rat gamma Catenin.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P), IHC(F) and ICC.

Background :

Junction plakoglobin(JUP), also known as gamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to β-catenin, and it is mapped to 17q21.2. This gene encodes a major cytoplasmic protein that is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins. Meanwhile, JUP may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes.

Reference :

1. Kolligs, F. T.; Kolligs, B.; Hajra, K. M.; Hu, G.; Tani, M.; Cho, K. R.; Fearon, E. R. : Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev. 14: 1319-1331, 2000. 2. "Entrez Gene: JUP junction plakoglobin

Gene Name :

JUP

Protein Name :

Junction plakoglobin

Gene Full Name :

junction plakoglobin

Synonyms :

ARVD 12 antibody ARVD12 antibody Catenin (cadherin associated protein) gamma 80kDa antibody Catenin (cadherin associated protein), gamma 80kDa antibody catenin (cadherin-associated protein) gamma (80kD) antibody Catenin gamma 80kDa antibody Catenin gamma antibody CTNNG antibody Desmoplakin 3 antibody Desmoplakin III antibody Desmoplakin-3 antibody Desmoplakin3 antibody DesmoplakinIII antibody DP 3 antibody DP III antibody DP3 antibody DPIII antibody Gamma catenin antibody Junction plakoglobin antibody JUP antibody OTTHUMP00000164732 antibody OTTHUMP00000164735 antibody OTTHUMP00000164738 antibody PDGB antibody PKGB antibody PLAK_HUMAN antibody PLAKOGLOBIN antibody

Uniprot ID :

P14923

more info or order :

Boster Immunoleader product webpage