Anti-p63 Antibody | Boster Immunoleader PB9152 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-p63 Antibody

catalog :

PB9152

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-p63 Antibody

Catalog Number :

PB9152

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Tumor protein 63(TP63) detection. Tested with WB, IHC-P, ICC in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

WB,IHC-P,ICC

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human

Immunocytochemistry :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

WB: The detection limit for p63 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human p63 recombinant protein (Position: S311-E680). Human p63 shares 98% amino acid (aa) sequence identity with both mouse and rat p63.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P) and ICC.

Background :

Tumor protein p63 (TP63), also known as the p63 or TP73L is a protein that in humans is encoded by the TP63 gene. It is mapped to 3q28. TP63 is a member of the p53 family of transcription factors. This gene encodes for two main isoforms by alternative promoters (TAp63 and ΔNp63). TP63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity. It has been found that the combined loss of TP63 and p73 results in the failure of cells containing functional p53 to undergo apoptosis in response to DNA damage. TP63 is an essential regulator of stem cell maintenance in stratified epithelial tissues. Tp63 is also critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis.

Reference :

1. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F (September 1998). "p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities". Mol. Cell 2 (3): 305–16. 2. Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M, Ikawa S (July 1998). "Cloning and functional analysis of human p51, which structurally and functionally resembles p53". Nat. Med. 4 (7): 839–43. 3. Crum CP, McKeon FD (2010). "p63 in epithelial survival, germ cell surveillance, and neoplasia". Annu Rev Pathol 5: 349–71.

Gene Name :

TP63

Protein Name :

Tumor protein 63

Gene Full Name :

tumor protein p63

Synonyms :

AIS antibody Amplified in squamous cell carcinoma antibody B(p51A) antibody B(p51B) antibody Chronic ulcerative stomatitis protein antibody CUSP antibody DN p63 alpha 1 antibody DNp63 antibody EEC3 antibody Keratinocyte transcription factor antibody Keratinocyte transcription factor KET antibody KET antibody LMS antibody MGC115972 antibody MGC192897 antibody NBP antibody OFC8 antibody OTTHUMP00000209732 antibody OTTHUMP00000209733 antibody OTTHUMP00000209734 antibody OTTHUMP00000209735 antibody OTTHUMP00000209737 antibody OTTHUMP00000209738 antibody OTTHUMP00000209739 antibody OTTHUMP00000209740 antibody OTTHUMP00000209741 antibody OTTHUMP00000209742 antibody OTTHUMP00000209743 antibody OTTHUMP00000209744 antibody p40 antibody p51 antibody P51/P63 antibody p53 like transcription factor antibody p53 related protein antibody p53-related protein p63 antibody p53CP antibody p63 antibody P63_HUMAN antibody P73 antibody p73H antibody p73L antibody RHS antibody SHFM4 antibody TAp63alpha antibody TP53CP antibody TP53L antibody TP63 antibody TP73 antibody TP73L antibody Transformation related protein 63 antibody Transformation-related protein 63 antibody Trp53rp1 antibody Trp63 antibody Tumor protein 63 antibody tumor protein 63 kDa with strong homology to p53 antibody Tumor protein p53-competing protein antibody Tumor protein p53-like antibody tumor protein p63 antibody Tumor protein p63 deltaN isoform delta antibody Tumor protein p73 antibody tumor protein p73-like antibody

Uniprot ID :

Q9H3D4

more info or order :

Boster Immunoleader product webpage