Boster Immunoleader

antibody

Anti-LRP1 Antibody

PB9143

100 ug/vial

240 USD

polyclonal

rabbit

Anti-LRP1 Antibody

PB9143

Polyclonal

Rabbit IgG polyclonal antibody for Prolow-density lipoprotein receptor-related protein 1(LRP1) detection. Tested with WB in Human.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human LRP1 recombinant protein (Position: A4351-A4544). Human LRP1 shares 86% amino acid (aa) sequence identity with mouse LRP1.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

LRP1, also known as Low density lipoprotein receptor-related protein 1 or CD91, is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. It is mapped to 12q13.3. In humans, the LRP1 protein is encoded by the LRP1 gene. It is mapped to 12q13.3. LRP1 is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. LRP1 showed strong calcium binding. It mediates the endocytosis and degradation of secreted amyloid precursor protein, suggesting that a single metabolic pathway links 2 molecules implicated in the pathophysiology of Alzheimer disease, LRP1 has a role in macrophage migration and that it is critical for internalization of integrin alpha-M/beta-2.

1. Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohl, H., Stanley, K. K. Surface location and high affinity for calcium of a 500 kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J. 7: 4119-4127, 1988. 2. Kounnas, M. Z., Moir, R. D., Rebeck, G. W., Bush, A. I., Argraves, W. S., Tanzi, R. E., Hyman, B. T., Strickland, D. K. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 82: 331-340, 1995. 3. Ranganathan, S., Cao, C., Catania, J., Migliorini, M., Zhang, L., Strickland, D. K. Molecular basis for the interaction of low density lipoprotein receptor-related protein 1 (LRP1) with integrin alpha-M/beta-2: identification of binding sites within alpha-M/beta-2 for LRP1. J. Biol. Chem. 286: 30535-30541, 2011.

LRP1

Prolow-density lipoprotein receptor-related protein 1

low density lipoprotein receptor-related protein 1

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Q07954