Anti-CD11a Antibody | Boster Immunoleader PB9139 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CD11a Antibody

catalog :

PB9139

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

publications citing this reagent :

Wang H, Li Y. Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and D-galactosamine in mice. Eur J Pharmacol. 2006;534:194-201 pubmed

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-CD11a Antibody

Catalog Number :

PB9139

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Integrin alpha-L(ITGAL) detection. Tested with WB in Human.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

WB: The detection limit for CD11a is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived human CD11a recombinant protein (Position: Q148-E523). Human CD11a shares 77% mino acid (aa) sequence identity with mouse CD11a.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

CD11a, also known as ITGAL or LFA-1, is a human gene which functions in the immune system. It is mapped to 16p11.2. CD11a is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. CD11a encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. It is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.

Reference :

1. "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)" 2. Marlin, S. D., Morton, C. C., Anderson, D. C., Springer, T. A. LFA-1 immunodeficiency disease: definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells. J. Exp. Med. 164: 855-867, 1986.

Gene Name :

ITGAL

Protein Name :

Integrin alpha-L

Gene Full Name :

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Synonyms :

Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody Antigen CD11A antibody CD 11a antibody CD11 antigen-like family member A antibody CD11a antibody CD11a antigen antibody Integrin Alpha L antibody Integrin alpha-L antibody Integrin gene promoter antibody Integrin, alpha L (antigen CD11A (p180), lymphocyte function associated antigen 1; alpha polypeptide) antibody ITAL_HUMAN antibody ITGAL antibody ITGAL protein antibody Leukocyte adhesion glycoprotein LFA 1 alpha chain antibody Leukocyte adhesion glycoprotein LFA-1 alpha chain antibody Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain antibody Leukocyte function associated molecule 1 alpha chain antibody Leukocyte function-associated molecule 1 alpha chain antibody LFA 1 alpha antibody LFA 1 antibody LFA 1A antibody LFA-1A antibody LFA1A antibody Ly15 antibody Ly21 antibody Lymphocyte function associated antigen 1 antibody Lymphocyte Function Associated Antigen Type 1 alpha antibody p180 antibody

Uniprot ID :

P20701

more info or order :

Boster Immunoleader product webpage