Boster Immunoleader

antibody

Anti-CTNNA1 Antibody

PB9137

100 ug/vial

240 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

Anti-CTNNA1 Antibody

PB9137

Polyclonal

Rabbit IgG polyclonal antibody for Catenin alpha-1(CTNNA1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

240 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse, rat

WB,IHC-P,IHC-F

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat

Concentration: 0.5-1μg/ml; Tested Species: Human, Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Rat

WB: The detection limit for CTNNA1 is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P) and IHC(F).

CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.

1. Vasioukhin, V., Bauer, C., Degenstein, L., Wise, B., Fuchs, E. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104: 605-617, 2001. 2. Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (November 1991). "The uvomorulin-anchorage protein alpha catenin is a vinculin homologue". Proc Natl Acad Sci U S A 88 (20): 9156–60. 3. "Entrez Gene: CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa

CTNNA1

Catenin alpha-1

catenin (cadherin-associated protein), alpha 1, 102kDa

alpha catenin antibody alpha E catenin antibody Alpha E-catenin antibody alphaE catenin antibody Cadherin associated protein 102kDa antibody Cadherin associated protein antibody Cadherin-associated protein antibody CAP 102 antibody CAP102 antibody Catenin (cadherin associated protein) alpha 1 102kDa antibody Catenin (cadherin associated protein), alpha 1, 102kDa antibody Catenin alpha 1 antibody Catenin alpha-1 antibody CTNA1_HUMAN antibody CTNNA 1 antibody CTNNA1 antibody FLJ36832 antibody FLJ52416 antibody NY REN 13 antigen antibody OTTHUMP00000224141 antibody OTTHUMP00000224147 antibody Renal carcinoma antigen NY REN 13 antibody Renal carcinoma antigen NY-REN-13 antibody

P35221