Anti-beta Amyloid Antibody | Boster Immunoleader PB9091 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-beta Amyloid Antibody

catalog :

PB9091

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry - paraffin section

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product information

Availability :

info changed 20150330

Product Name :

Anti-beta Amyloid Antibody

Catalog Number :

PB9091

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Amyloid beta A4 protein(APP) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Mouse, Rat; Predicted Species: Human

Notes :

WB: The detection limit for beta Amyloid is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

different from the related mouse and rat sequences by three amino acids.
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGV
VIA),
A synthetic peptide corresponding to a sequence at the C-terminus of human beta Amyloid(672-713aa

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

beta Amyloid, also called Abeta or Abeta, denotes peptides of 36–43 amino acidsthat are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. It is mapped to 19q13.12. Several potential activities have been discovered for beta Amyloid, including activation of kinase enzymes, functioning as atranscription factor, and anti-microbial activity (potentially associated with beta Amyloid's pro-inflammatoryactivity). Moreover, monomeric beta Amyloid is indicated to protect neurons by quenching metal-inducible oxygen radical generation and thereby inhibiting neurotoxicity.

Reference :

1. Zou K, Gong JS, Yanagisawa K, Michikawa M (June 2002). "A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage".J. Neurosci. 22 (12): 4833–41. 2. Tabaton M, Zhu X, Perry G, Smith MA, Giliberto L (January 2010). "Signaling Effect of Amyloid-β42 on the Processing of AβPP". Exp. Neurol. 221 (1): 18–25. 3. Baruch-Suchodolsky R, Fischer B (May 2009). "Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems". Biochemistry 48 (20): 4354–70. 4. Igbavboa U, Sun GY, Weisman GA, He Y, Wood WG (August 2009). "Amyloid β-Protein Stimulates Trafficking of Cholesterol and Caveolin-1 from the Plasma Membrane to the Golgi Complex in Mouse Primary Astrocytes". Neuroscience 162 (2): 328–38.

Gene Name :

APP

Protein Name :

Amyloid beta A4 protein

Gene Full Name :

amyloid beta (A4) precursor protein

Synonyms :

A4 antibody A4 antibody A4_HUMAN antibody AAA antibody AAA antibody ABETA antibody ABETA antibody ABPP antibody ABPP antibody AD1 antibody AICD-50 antibody AICD-57 antibody AICD-59 antibody AID(50) antibody AID(57) antibody AID(59) antibody Alzheimer disease amyloid protein antibody Alzheimers Disease Amyloid Protein antibody Amyloid B antibody amyloid beta (A4) precursor protein antibody amyloid beta A4 protein antibody Amyloid Beta A4 Protein Precursor antibody Amyloid Beta antibody Amyloid intracellular domain 50 antibody Amyloid intracellular domain 57 antibody Amyloid intracellular domain 59 antibody Amyloid of Aging and Alzheimer Disease antibody APP antibody APPI antibody APPI antibody B Amyloid antibody Beta APP antibody beta-amyloid peptide antibody Beta-APP40 antibody Beta-APP42 antibody C31 antibody Cerebral Vascular Amyloid Peptide antibody CTFgamma antibody CVAP antibody CVAP antibody Gamma-CTF(50)antibody Gamma-CTF(57) antibody Gamma-CTF(59) antibody peptidase nexin-II antibody PN II antibody PN-II antibody PN2 antibody PreA4 antibody PreA4 antibody Protease nexin II antibody Protease nexin-II antibody S-APP-alpha antibody S-APP-beta antibody

Uniprot ID :

P05067

more info or order :

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