Anti-Eotaxin Antibody | Boster Immunoleader PB9065 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Eotaxin Antibody

catalog :

PB9065

quantity :

100 ug/vial

price :

240 USD

clonality :

polyclonal

host :

rabbit

reactivity :

mouse

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Eotaxin Antibody

Catalog Number :

PB9065

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Eotaxin(CCL11) detection. Tested with WB in Mouse.

Price :

240 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse

Notes :

WB: The detection limit for Eotaxin is approximately 0.25ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

E.coli-derived mouse Eotaxin recombinant protein (Position: H24-P97). Mouse Eotaxin shares 62% and 97% amino acid (aa) sequences identity with human and rat Eotaxin, respectively.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

CCL11, also known as Eotaxin, is a potent inducer of eosinophil chemotaxis and is considered as a selective ligand of the CC chemokine receptor 3(CCR3), which is expressed on eosinophils, basophils, and Th2 lymphocytes. The gene maps to chromosome 17 and is expressed constitutively at high levels in small intestine and colon, and at lower levels in various other tissues. CCL11 is a small cytokine belonging to the CC chemokine family. It is assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor.

Reference :

1. Ogilvie, P.; Bardi, G.; Clark-Lewis, I.; Baggiolini, M.; Uguccioni, M. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood 97: 1920-1924, 2001. 2. Hein, H.; Schluter, C.; Kulke, R.; Christophers, E.; Schroder, J.-M.; Bartels, J. Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene. Biochem. Biophys. Res. Commun. 237: 537-542, 1997.

Gene Name :

CCL11

Protein Name :

Eotaxin

Gene Full Name :

chemokine (C-C motif) ligand 11

Synonyms :

C-C motif chemokine 11 antibody CCL 11 antibody CCL11 antibody CCL11_HUMAN antibody chemokine (C-C motif) ligand 11 antibody Chemokine C C motif ligand 11 antibody Chemokine CC Motif Ligand 11 antibody Chemokine ligand 11 antibody Eosinophil chemotactic protein antibody Eotaxin antibody eotaxin-1 antibody MGC22554 antibody SCYA 11 antibody SCYA11 antibody Small inducible cytokine A11 antibody Small inducible cytokine subfamily A (Cys Cys) member 11 antibody small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin) antibody Small inducible cytokine subfamily A member 11 antibody Small-inducible cytokine A11 antibody

Uniprot ID :

P48298

more info or order :

Boster Immunoleader product webpage