Boster Immunoleader

antibody

Anti-MUC1 Antibody

PA2302

100 ug/vial

200 USD

polyclonal

rabbit

Anti-MUC1 Antibody

PA2302

Polyclonal

Rabbit IgG polyclonal antibody for Mucin-1(Mucin 1) detection. Tested with WB in Human.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human MUC1(1067-1083aa QELQRDISEMFLQIYKQ).

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Mucin 1, cell surface associated(MUC1) or polymorphic epithelial mucin(PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its antiinflammatory activity may play an important modulatory role during microbial infection.

1. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D (September 1990). "Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin". J. Biol. Chem. 265 (25): 15286–93. 2. Wei, X., Xu, H., Kufe, D. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Molec. Cell 21: 295-305, 2006. 3. Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W., Cross, A. S., Gendler, S. J., Gewirtz, A. T., Kim, K. C. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J. Immun. 176: 3890-3894, 2006.

Mucin 1

Mucin-1

mucin 1, cell surface associated

Breast carcinoma associated antigen DF3 antibody Breast carcinoma-associated antigen DF3 antibody CA 15-3 antibody CA15 3 antibody CA15 3 antigen antibody CA15.3 antibody Cancer antigen 15-3 antibody Carcinoma associated mucin antibody Carcinoma-associated mucin antibody CD 227 antibody CD227 antibody DF3 antigen antibody EMA antibody Episialin antibody H23 antigen antibody H23AG antibody KL 6 antibody KL-6 antibody KL6 antibody Krebs von den Lungen-6 antibody MAM 6 antibody MAM6 antibody MUC 1 antibody MUC-1 antibody MUC-1/SEC antibody MUC-1/X antibody MUC1 antibody MUC1-alpha antibody MUC1-beta antibody MUC1-CT antibody MUC1-NT antibody MUC1/ZD antibody MUC1_HUMAN antibody Mucin 1 antibody Mucin 1 transmembrane antibody Mucin-1 subunit beta antibody Peanut reactive urinary mucin antibody Peanut-reactive urinary mucin antibody PEM antibody PEMT antibody Polymorphic epithelial mucin antibody PUM antibody Tumor associated epithelial membrane antigen antibody Tumor associated epithelial mucin antibody Tumor associated mucin antibody Tumor-associated epithelial membrane antigen antibody Tumor-associated mucin antibody

P15941