Boster Immunoleader

antibody

Anti-KCNC1 Antibody

PA2298

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-KCNC1 Antibody

PA2298

Polyclonal

Rabbit IgG polyclonal antibody for Potassium voltage-gated channel subfamily C member 1(KCNC1) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: mouse, rat Predicted to work with: human

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat; Predicted Species: Human

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human KCNC1(494-511aa EILEINRAGRKPLRGMSI), identical to the related mouse and rat sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Potassium voltage-gated channel subfamily C member 1, also known as KV3.1, is a protein that in humans is encoded by the KCNC1 gene. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins, and it is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. This gene is mapped to 11p15.1. KCNC1 channels are prominently expressed in brain, and in retinal ganglion cells. High amounts of KCNC1 current decreased the timing accuracy of action potentials but enabled neurons to follow high-frequency stimuli. KCNC1 channels are important for the high-firing frequency of auditory and fast-spiking GABAergic interneurons, retinal ganglion cells; regulation of action potential duration in presynaptic terminals.

1. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol Rev 57 (4): 473–508. 2. Ried T, Rudy B, Vega-Saenz de Miera E, Lau D, Ward DC, Sen K (Apr 1993). "Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15". Genomics 15 (2): 405–11. 3. Song, P., Yang, Y., Barnes-Davies, M., Bhattacharjee, A., Hamann, M., Forsythe, I. D., Oliver, D. L., Kaczmarek, L. K. Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons. Nature Neurosci. 8: 1335-1342, 2005.

KCNC1

Potassium voltage-gated channel subfamily C member 1

potassium voltage-gated channel, Shaw-related subfamily, member 1

C230009H10Rik antibody FLJ41162 antibody FLJ42249 antibody FLJ43491 antibody Kcr2 1 antibody KShIIIB antibody Kv3.1 antibody Kv4 antibody MGC129855 antibody NGK2 antibody Potassium voltage-gated channel subfamily C member 1 antibody Shaw antibody Voltage gated potassium channel antibody Voltage gated potassium channel subunit Kv3.1 antibody Voltage-gated potassium channel subunit Kv3.1 antibody

P48547