Boster Immunoleader

antibody

Anti-PSD95 Antibody

PA2295

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-PSD95 Antibody

PA2295

Polyclonal

Rabbit IgG polyclonal antibody for Disks large homolog 4(DLG4) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human PSD95(492-507aa RRVERREWSRLKAKDW), identical to the related rat and mouse sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

DLG4 discs large homolog 4, also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase(MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.

1. Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., Scott, J. D. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 40: 595-607, 2003. 2. El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., Bredt, D. S. PSD-95 involvement in maturation of excitatory synapses. Science 290: 1364-1368, 2000. 3. "Entrez Gene: DLG4 discs, large homolog 4 (Drosophila)

DLG4

Disks large homolog 4

discs, large homolog 4(Drosophila)

Discs large homolog 4 antibody Disks large homolog 4 antibody DLG 4 antibody DLG4 antibody DLG4_HUMAN antibody FLJ97752 antibody FLJ98574 antibody Human post synaptic density protein 95 antibody Human post-synaptic density protein 95 antibody Post synaptic density protein 95 antibody Postsynaptic density protein 95 antibody PSD 95 antibody PSD-95 antibody PSD95 antibody SAP 90 antibody SAP-90 antibody SAP90 antibody Synapse associated protein 90 antibody Synapse-associated protein 90 antibody Tax interaction protein 15 antibody

P78352