Boster Immunoleader

antibody

Anti-CACNA1A Antibody

PA2292

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-CACNA1A Antibody

PA2292

Polyclonal

Rabbit IgG polyclonal antibody for Voltage-dependent P/Q-type calcium channel subunit alpha-1A(CACNA1A) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: rat Predicted to work with: human, mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human CACNA1A(430-447aa KTDLLNPEEAEDQLADIA), identical to the related mouse and rat sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

The CACNA1A gene, also known as CACNL1A4 or CaV2.1, encodes the transmembrane pore-forming subunit of the P/Q-type or CaV2.1 voltage-gated calcium channel(VGCC). Those channels not only mediate the entry of Ca(2+) ions into excitable cells but are also involved in a variety of Ca(2+)-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. The channel activity is directed by the pore-forming alpha-1 subunit. CACNA1A is mapped to 19p13.2. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to(CAG)n-repeats. CACNA1A has been shown to interact with CACNB4.

1. "Entrez Gene: CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit" 2. Kordasiewicz, H. B., Thompson, R. M., Clark, H. B., Gomez, C. M. C-termini of P/Q-type Ca(2+) channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity. Hum. Molec. Genet. 15: 1587-1599, 2006. 3. Diriong, S., Lory, P., Williams, M. E., Ellis, S. B., Harpold, M. M., Taviaux, S.Chromosomal localization of the human genes for alpha-1A, alpha-1B, and alpha-1E voltage-dependent Ca(2+) channel subunits. Genomics 30: 605-609, 1995.

CACNA1A

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

APCA antibody BI antibody Brain calcium channel 1 antibody Brain calcium channel I antibody Cach4 antibody Cacn3 antibody Cacna1a antibody Cacnl1a4 antibody Calcium channel alpha 1A subunit antibody Calcium channel L type alpha 1 polypeptide antibody Calcium channel L type alpha-1 polypeptide isoform 4 antibody Calcium channel voltage dependent, P/Q type alpha 1A subunit antibody CAV2.1 antibody EA2 antibody FHM antibody HPCA antibody MHP antibody MHP1 antibody RAT brain class A antibody RBA-I antibody SCA6 antibody Voltage-dependent P/Q-type calcium channel alpha-1A subunit antibody Voltage-gated calcium channel alpha subunit Cav2.1 antibody

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