Boster Immunoleader

antibody

Anti-TAB2 Antibody

PA2289

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-TAB2 Antibody

PA2289

Polyclonal

Rabbit IgG polyclonal antibody for TGF-beta-activated kinase 1/MAP3K7-binding protein 2(TAB2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, mouse, rat

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Concentration: 0.5-1μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human TAB2(487-506aa LTNLLNHPDHYVETENIQHL), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, also known as TAB2, is an enzyme that in humans is encoded by the MAP3K7IP2 gene. The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2 functionally links TAK1 to TRAF6. What's more, TAB2 can act as a sensor for inflammatory signals by serving as a molecular beacon for recruitment of MEKK1(MAP3K1), which in turn mediated dismissal of the NCOR/HDAC complex and permitted derepression of AR and estrogen receptor target genes.

1. Takaesu, G., Kishida, S., Hiyama, A., Yamaguchi, K., Shibuya, H., Irie, K., Ninomiya-Tsuji, J., Matsumoto, K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.Molec. Cell 5: 649-658, 2000. 2. "Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2" 3. Zhu, P., Baek, S. H., Bourk, E. M., Ohgi, K. A., Garcia-Bassets, I., Sanjo, H., Akira, S., Kotol, P. F., Glass, C. K., Rosenfeld, M. G., Rose, D. W. Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 124: 615-629, 2006.

TAB2

TGF-beta-activated kinase 1/MAP3K7-binding protein 2

TGF-beta activated kinase 1/MAP3K7 binding protein 2

CHTD2 antibody FLJ21885 antibody KIAA0733 antibody MAP3K7IP2 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody OTTHUMP00000040125 antibody TAB 2 antibody TAB-2 antibody Tab2 antibody TAK1 binding protein 2 antibody TAK1-binding protein 2 antibody TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody TGF-beta-activated kinase 1-binding protein 2 antibody

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