Boster Immunoleader

antibody

Anti-SIRT2 Antibody

PA2283

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-SIRT2 Antibody

PA2283

Polyclonal

Rabbit IgG polyclonal antibody for NAD-dependent protein deacetylase sirtuin-2(SIRT2) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human SIRT2(54-72aa QKERLLDELTLEGVARYMQ), different from the related mouse and rat sequences by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT2 is mapped to 19q13.2. It is able to cause radioactivity to be transferred from(32P) NAD to bovine serum albumin(BSA). According to researches, SIRT2 can act as a bona fide tubulin deacetylase. SIRT2 was found to deacetylate lys40 of alpha-tubulin both in vitro and in vivo. SIRT2 is also a regulator of mitotic progression that acts downstream from CDC14B in a pathway regulating mitotic exit or subsequent cytokinesis. What's more, SIRT2 is an important regulator of programmed necrosis.

1. Dryden, S. C., Nahhas, F. A., Nowak, J. E., Goustin, A.-S., Tainsky, M. A. Role for humanSIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Molec. Cell Biol. 23: 3173-3185, 2003. 2. "Entrez Gene: SIRT2 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)" 3. North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., Verdin, E. The human Sir2 ortholog, SIRT2, is an NAD(+)-dependent tubulin deacetylase. Molec. Cell 11: 437-444, 2003.

SIRT2

NAD-dependent protein deacetylase sirtuin-2

sirtuin 2

FLJ35621 antibody FLJ37491 antibody NAD dependent deacetylase sirtuin 2 antibody NAD-dependent deacetylase sirtuin-2 antibody Regulatory protein SIR2 homolog 2 antibody Silencing information regulator 2 like antibody Silent information regulator 2 antibody Silent mating type information regulation 2 antibody Silent mating type information regulation 2 homolog antibody SIR 2 antibody SIR2 antibody SIR2 like antibody SIR2 like protein 2 antibody Sir2 related protein type 2 antibody SIR2-like protein 2 antibody SIR2L antibody SIR2L2 antibody SIRT 2 antibody SIRT2 antibody Sirtuin(silent mating type information regulation 2 homolog) 2(S.cerevisiae) antibody Sirtuin 2 antibody Sirtuin type 2 antibody Sirtuin2 antibody

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