Boster Immunoleader

antibody

Anti-SRC3 Antibody

PA2277

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-SRC3 Antibody

PA2277

Polyclonal

Rabbit IgG polyclonal antibody for Nuclear receptor coactivator 3(NCOA3) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse, rat

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse, Rat

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human SRC3(1043-1061aa NLEGQSDERALLDQLHTLL), different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. It is mapped to 20q13.12. This gene was amplified and overexpressed in breast and ovarian cancer cell lines, as well as in breast cancer biopsies, and altered NCOA3 expression may contribute to development of steroid-dependent cancers. NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. In addition to those, this gene is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.

1. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (August 1997). "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer". Science 277 (5328): 965–8. 2. Chen, H., Lin, R. J., Schiltz, R. L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M. L., Nakatani, Y., Evans, R. M. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90: 569-580, 1997. 3. Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (October 1997). "TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1". J. Biol. Chem. 272 (44): 27629–34.

NCOA3

Nuclear receptor coactivator 3

nuclear receptor coactivator 3

ACTR antibody AIB 1 antibody AIB-1 antibody AIB1 antibody Amplified in breast cancer 1 antibody Amplified in breast cancer 1 protein antibody bHLHe42 antibody CAGH 16 antibody CAGH16 antibody CBP interacting protein antibody CBP-interacting protein antibody Class E basic helix-loop-helix protein 42 antibody CTG 26 antibody CTG26 antibody KAT13B / AIB1 antibody MGC141848 antibody NCOA 3 antibody NCoA-3 antibody NCOA3 antibody Nuclear receptor coactivator 3 antibody pCIP antibody RAC 3 antibody RAC-3 antibody RAC3 antibody Receptor associated coactivator 3 antibody Receptor-associated coactivator 3 antibody SRC 3 antibody SRC-3 antibody SRC3 antibody Steroid receptor coactivator protein 3 antibody Thyroid hormone receptor activator molecule 1 antibody TNRC14 antibody TNRC16 antibody TRAM 1 antibody TRAM-1 antibody TRAM1 antibody

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