Anti-MEK4 Antibody | Boster Immunoleader PA2275 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-MEK4 Antibody

catalog :

PA2275

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-MEK4 Antibody

Catalog Number :

PA2275

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Dual specificity mitogen-activated protein kinase kinase 4(MAP2K4) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human MEK4(360-378aa ELLKHPFILMYEERAVEVA), different from the related mouse and rat sequences by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Dual specificity mitogen-activated protein kinase kinase 4(MAP2K4), also called SEK1 or JNKK1, is an enzyme that in humans is encoded by the MAP2K4 gene. It is mapped to 17p12. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. MAP2K4 was a specific activator of JNK1, JNK2, and p38, and it has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.

Reference :

1. "Entrez Gene: MAP2K4 mitogen-activated protein kinase kinase 4" 2. Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M (May 1995). "Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2".Science 268 (5208): 286–90.

Gene Name :

MAP2K4

Protein Name :

Dual specificity mitogen-activated protein kinase kinase 4

Gene Full Name :

mitogen-activated protein kinase kinase 4

Synonyms :

c Jun N terminal kinase kinase 1 antibody C-JUN N-terminal kinase kinase 1 antibody Dual specificity mitogen activated protein kinase kinase 4 antibody Dual specificity mitogen-activated protein kinase kinase 4 antibody JNK Activated Kinase 1 antibody JNK activating kinase 1 antibody JNK-activating kinase 1 antibody JNKK antibody JNKK1 antibody MAP kinase kinase 4 antibody Map2k4 antibody MAPK ERK kinase 4 antibody MAPK/ERK kinase 4 antibody MAPKK 4 antibody MAPKK4 antibody MEK 4 antibody MEK4 antibody Mitogen activated protein kinase kinase 4 antibody MKK 4 antibody MKK4 antibody PRKMK4 antibody SAPK ERK kinase 1 antibody SAPK/ERK kinase 1 antibody SEK1 antibody SERK1 antibody

Uniprot ID :

P45985

more info or order :

Boster Immunoleader product webpage