Anti-LRP5 Antibody | Boster Immunoleader PA2273 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-LRP5 Antibody

catalog :

PA2273

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-LRP5 Antibody

Catalog Number :

PA2273

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Low-density lipoprotein receptor-related protein 5(LRP5) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: mouse, rat Predicted to work with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Mouse, Rat; Predicted Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5(1201-1215aa IHAVEEVSLEEFSAH), identical to the related mouse and rat sequences.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. It is mapped to 11q13.2. LRP5 is a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling.

Reference :

1. Hey PJ, Twells RC, Phillips MS, Yusuke Nakagawa, Brown SD, Kawaguchi Y, Cox R, Guochun Xie, Dugan V, Hammond H, Metzker ML, Todd JA, Hess JF (Oct 1998). "Cloning of a novel member of the low-density lipoprotein receptor family". Gene 216 (1): 103–11. 2. "Entrez Gene: LRP5 low density lipoprotein receptor-related protein 5" 3. Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., III, Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., Wu, D. Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signaling pathway. Molec. Cell 7: 801-809, 2001.

Gene Name :

LRP5

Protein Name :

Low-density lipoprotein receptor-related protein 5

Gene Full Name :

low density lipoprotein receptor-related protein 5

Synonyms :

BMND1 antibody EVR1 antibody EVR4 antibody HBM antibody HGNC:6697 antibody Low density lipoprotein receptor related protein 5 antibody Low density lipoprotein receptor related protein 7 antibody Low-density lipoprotein receptor-related protein 5 antibody LR3 antibody LRP-5 antibody Lrp5 antibody LRP7 antibody OPPG antibody OPS antibody OPTA1 antibody Osteoporosis pseudoglioma syndrome antibody VBCH2 antibody

Uniprot ID :

O75197

more info or order :

Boster Immunoleader product webpage