Anti-CSEN Antibody | Boster Immunoleader PA2272 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-CSEN Antibody

catalog :

PA2272

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-CSEN Antibody

Catalog Number :

PA2272

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Calsenilin(KCNIP3) detection. Tested with WB in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the N-terminus of human CSEN(1-16aa MQPAKEVTKASDGSLL).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

KCNIP3, also known as Calsenilin, is a calcium-dependent transcriptional repressor that is highly expressed in central nervous system, thyroid gland, testis, thymus, and immune cells. This gene encodes a member of the family of voltage-gated potassium(Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. KCNIP3 is mapped to 2q11.1. The encoded protein functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. KCNIP3-regulated genes have a critical function in Ig subclass production and proliferation in B lymphocytes. KCNIP3 has been shown to interact with PSEN1 and PSEN2.

Reference :

1. Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor".Nature 398 (6722): 80–4. 2. "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin" 3. Savignac, M., Mellstrom, B., Bebin, A.-G., Oliveros, J. C., Delpy, L., Pinaud, E., Naranjo, J. R. Increased B cell proliferation and reduced Ig production in DREAM transgenic mice. J. Immun. 185: 7527-7536, 2010.

Gene Name :

KCNIP3

Protein Name :

Calsenilin

Gene Full Name :

Kv channel interacting protein 3, calsenilin

Synonyms :

4933407H12Rik antibody A type potassium channel modulatory protein 3 antibody A-type potassium channel modulatory protein 3 antibody AI413860 antibody Calsenilin antibody CSEN antibody DRE Antagonist Modulator antibody DRE-antagonist modulator antibody DREAM antibody EF Hand Transcription Factor antibody KCHIP 3 antibody KCHIP3 antibody KCNIP 3 antibody KCNIP3 antibody Kv channel interacting protein 3 antibody Kv channel-interacting protein 3 antibody MGC18289 antibody Potassium channel interacting protein 3 antibody Presenilin Binding Protein antibody R74849 antibody

Uniprot ID :

Q9Y2W7

more info or order :

Boster Immunoleader product webpage