Anti-JAB1 Antibody | Boster Immunoleader PA2265 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-JAB1 Antibody

catalog :

PA2265

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-JAB1 Antibody

Catalog Number :

PA2265

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for COP9 signalosome complex subunit 5(COPS4) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, mouse, rat

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Mouse, Rat

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human JAB1(318-334aa LMSQVIKDKLFNQINIS), different from the related mouse and rat sequences by two amino acids.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

COP9 constitutive photomorphogenic homolog subunit 5(Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.

Reference :

1. Bianchi, E., Denti, S., Granata, A., Bossi, G., Geginat, J., Villa, A., Rogge, L., Pardi, R.Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature 404: 617-621, 2000. 2. "Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)" 3. Hallstrom, T. C., Nevins, J. R. Jab1 is a specificity factor for E2F1-induced apoptosis.Genes Dev. 20: 613-623, 2006.

Gene Name :

COPS5

Protein Name :

COP9 signalosome complex subunit 5

Gene Full Name :

COP9 signalosome subunit 5

Synonyms :

38 kDa Mov34 homolog antibody COP9(constitutive photomorphogenic) homolog subunit 5 antibody COP9 constitutive photomorphogenic homolog subunit 5 antibody COP9 signalosome complex subunit 5 antibody COP9 signalosome subunit 5 antibody Cop9 subunit 5 antibody COPS 5 antibody COPS5 antibody CSN 5 antibody CSN5 antibody JAB 1 antibody Jun activation domain binding protein 1 antibody Jun activation domain binding protein antibody Jun activation domain-binding protein 1 antibody Jun activation domain-binding protein antibody MGC3149 antibody MOV 34 antibody MOV34 antibody MOV34 family, 38-KD member antibody SGN 5 antibody SGN5 antibody Signalosome subunit 5 antibody

Uniprot ID :

Q92905

more info or order :

Boster Immunoleader product webpage