Boster Immunoleader

antibody

Anti-PARP Antibody

PA2227

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-PARP Antibody

PA2227

Polyclonal

Rabbit IgG polyclonal antibody for Poly[ADP-ribose] polymerase 1(PARP1) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: rat Predicted to work with: human, mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human PARP(78-91aa RWDDQQKVKKTAEA), identical to the related mouse and rat sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Poly[ADP-ribose] polymerase 1(PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

1. Ambrose, H. E., Willimott, S., Beswick, R. W., Dantzer, F., Menissier de Murcia, J., Yelamos, J., Wagner, S. D. Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses. Immunology 127: 178-186, 2008. 2. Doege, C. A., Inoue, K., Yamashita, T., Rhee, D. B., Travis, S., Fujita, R., Guarnieri, P., Bhagat, G., Vanti, W. B., Shih, A., Levine, R. L., Nik, S., Chen, E. I., Abeliovich, A. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature 488: 652-655, 2012.

PARP1

Poly [ADP-ribose] polymerase 1

poly(ADP-ribose) polymerase 1

ADP ribosyltransferase(NAD+; poly(ADP ribose) polymerase) antibody ADP ribosyltransferase diphtheria toxin like 1 antibody ADP ribosyltransferase NAD(+) antibody ADP ribosyltransferase NAD+ antibody ADPRT 1 antibody ADPRT antibody ADPRT1 antibody ARTD1 antibody msPARP antibody NAD(+) ADP ribosyltransferase 1 antibody NAD(+) ADP-ribosyltransferase 1 antibody pADPRT 1 antibody pADPRT1 antibody PARP 1 antibody PARP antibody PARP-1 antibody PARP1 antibody PARP1_HUMAN antibody Poly(ADP ribose) polymerase 1 antibody poly(ADP ribose) polymerase family, member 1 antibody Poly [ADP-ribose] polymerase 1 antibody Poly adenosine diphosphate ADP ribose polymerase antibody Poly ADP ribose polymerase 1 antibody Poly ADP ribose polymerase family member 1 antibody Poly ADP ribose synthetase 1 antibody Poly(ADP ribose) polymerase antibody poly(ADP ribose) synthetase antibody poly(ADP ribosyl)transferase antibody Poly[ADP ribose] synthetase 1 antibody Poly[ADP-ribose] synthase 1 antibody PPOL antibody

P09874