Anti-Ihh Antibody | Boster Immunoleader PA2225 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-Ihh Antibody

catalog :

PA2225

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat

application :

western blot

more info or order :

Boster Immunoleader product webpage

product information

Product Name :

Anti-Ihh Antibody

Catalog Number :

PA2225

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Indian hedgehog protein(IHH) detection. Tested with WB in Human;Mouse;Rat.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human, rat Predicted to work with: mouse

Applications :

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence at the C-terminus of human Ihh(250-264aa EPHRLRAFQVIETQD), different from the related mouse and rat sequences by one amino acid.

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Background :

Indian hedgehog, also known as IHH or HHG2 is a protein which in humans is encoded by the IHH gene. This gene encodes a member of the hedgehog family of secreted signaling molecules. IHH gene is mapped to 2q35. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth a differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia.

Reference :

1. Berman, D. M., Karhadkar, S. S., Maitra, A., Montes de Oca, R., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., Beachy, P. A. Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425: 846-851, 2003. 2. Chung, U., Schipani, E., McMahon, A. P., Kronenberg, H. M. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J. Clin. Invest. 107: 295-304, 2001. 3. Giordano, N., Gennari, L., Bruttini, M., Mari, F., Meloni, I., Baldi, C., Capoccia, S., Geraci, S., Merlotti, D., Amendola, A., Martini, G., Nuti, R., Gennari, C., Renieri, A. Mild brachydactyly type A1 maps to chromosome 2q35-q36 and is caused by a novel IHH mutation in a three generation family. J. Med. Genet. 40: 132-135, 2003.

Gene Name :

IHH

Protein Name :

Indian hedgehog protein

Gene Full Name :

indian hedgehog

Synonyms :

BDA1 antibody HHG-2 antibody HHG2 antibody IHH antibody IHH_HUMAN antibody Indian Hedgehog antibody Indian hedgehog homolog antibody Indian hedgehog protein antibody Indian hedgehog protein C-product antibody

Uniprot ID :

Q14623

more info or order :

Boster Immunoleader product webpage