Anti-alpha 1 Antichymotrypsin Antibody | Boster Immunoleader PA2217 product information

product summary

request information :

company name :

Boster Immunoleader

product type :

antibody

product name :

Anti-alpha 1 Antichymotrypsin Antibody

catalog :

PA2217

quantity :

100 ug/vial

price :

200 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

western blot, immunohistochemistry - paraffin section

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product information

Product Name :

Anti-alpha 1 Antichymotrypsin Antibody

Catalog Number :

PA2217

Clonality :

Polyclonal

Description short :

Rabbit IgG polyclonal antibody for Alpha-1-antichymotrypsin(SERPINA3) detection. Tested with WB, IHC-P in Human.

Price :

200 USD

Ig type :

Rabbit IgG

Size :

100 ug/vial

Form :

Lyophilized

Specificity :

No cross reactivity with other proteins.

Reactivity :

Reacts with: human

Applications :

WB,IHC-P

Western blot :

Concentration: 0.1-0.5μg/ml; Tested Species: Human

Immunohistochemistry(Paraffin-embedded S ... :

Concentration: 0.5-1μg/ml; Tested Species: Human

Notes :

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human alpha 1 Antichymotrypsin(218-232aa EMPFDPQDTHQSRFY).

Contents :

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Purification :

Immunogen affinity purified.

Reconstitution :

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage :

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Relevant detection systems :

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Background :

Alpha 1-antichymotrypsin, also called serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 3 or GIG24 is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. This gene is mapped to 14q32.13. The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Reference :

1. Chappell, S., Daly, L., Morgan, K., Baranes, T. G., Roca, J., Rabinovich, R., Millar, A., Donnelly, S. C., Keatings, V., MacNee, W., Stolk, J., Hiemstra, P., Miniati, M., Monti, S., O'Connor, C. M., Kalsheker, N. Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum. Mutat. 27: 103-109, 2006. 2. Wang, X., DeKosky, S. T., Luedecking-Zimmer, E., Ganguli, M., Kamboh, M. I. Genetic variation in alpha-1-antichymotrypsin and its association with Alzheimer's disease. Hum. Genet. 110: 356-365, 2002.

Gene Name :

SERPINA3

Protein Name :

Alpha-1-antichymotrypsin

Gene Full Name :

serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 3

Synonyms :

SERPINA3 antibody AACT antibody AACT_HUMAN antibody ACT antibody Alpha 1 Antichymotrypsin 1 antibody Alpha 1 Antichymotrypsin 2 antibody Alpha 1 Antichymotrypsin 3 antibody Alpha 1 Antitrypsin Deficiency antibody Alpha-1-antichymotrypsin His-Pro-less antibody Anti Elastase antibody Antichymotrypsin antibody Cell growth inhibiting gene 24/25 protein antibody Cell growth-inhibiting gene 24/25 protein antibody Clade A(Alpha 1 Antiproteinase Antitrypsin) antibody GIG24 antibody GIG25 antibody Growth inhibiting protein 24 antibody Growth inhibiting protein 25 antibody MGC88254 antibody PI1 antibody Protease Inhibitor 1 antibody Serine(or Cysteine) Proteinase Inhibitor antibody Serine(or cysteine) proteinase inhibitor clade A(alpha 1 antiproteinase, antitrypsin) member 3 antibody Serine(or cysteine) proteinase inhibitor clade A member 3 antibody Serine proteinase inhibitor clade A member 3 antibody Serpin A3 antibody Serpin peptidase inhibitor clade A(alpha 1 antiproteinase antitrypsin) member 3 antibody SERPINA1 antibody SERPINA2 antibody SERPINA3 antibody

Uniprot ID :

P01011

more info or order :

Boster Immunoleader product webpage