Boster Immunoleader

antibody

Anti-CFTR Antibody

PA2201

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

western blot, immunohistochemistry - paraffin section

Anti-CFTR Antibody

PA2201

Polyclonal

Rabbit IgG polyclonal antibody for Cystic fibrosis transmembrane conductance regulator(CFTR) detection. Tested with WB, IHC-P in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human, rat Predicted to work with: mouse

WB,IHC-P

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Concentration: 0.5-1μg/ml; Tested Species: Human, Rat; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the C-terminus of human CFTR(1463-1480aa QIAALKEETEEEVQDTRL), different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB, supported by SA1022 in IHC(P).

Cystic fibrosis transmembrane conductance regulator(CFTR), also called ABC35 or ABCC7, is a protein that in humans is encoded by the CFTR gene. This gene is mapped to 7q31.2. This gene encodes a member of the ATP-binding cassette(ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies(ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens.

1. Audrezet, M.-P., Chen, J.-M., Raguenes, O., Chuzhanova, N., Giteau, K., Le Marechal, C., Quere, I., Cooper, D. N., Ferec, C. Genomic rearrangements in the CFTR gene: extensive allelic heterogeneity and diverse mutational mechanisms. Hum. Mutat. 23: 343-357, 2004. 2. Di, A., Brown, M. E., Deriy, L. V., Li, C., Szeto, F. L., Chen, Y., Huang, P., Tong, J., Naren, A. P., Bindokas, V., Palfrey, H. C., Nelson, D. J. CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat. Cell Biol. 8: 933-944, 2006.

CFTR

Cystic fibrosis transmembrane conductance regulator

cystic fibrosis transmembrane conductance regulator(ATP-binding cassette sub-family C, member 7)

ABC 35 antibody ABC35 antibody ABCC 7 antibody ABCC7 antibody ATP binding cassette sub family C member 7 antibody ATP Binding Cassette Superfamily C Member 7 antibody ATP binding cassette transporter sub family C member 7 antibody ATP-binding cassette sub-family C member 7 antibody cAMP dependent chloride channel antibody cAMP-dependent chloride channel antibody CF antibody CFTR antibody CFTR/MRP antibody CFTR_HUMAN antibody Channel conductance controlling ATPase antibody Channel conductance-controlling ATPase antibody Cystic fibrosis transmembrane conductance regulator antibody Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7 antibody Cystic Fibrosis Transmembrane Regulator antibody dJ760C5.1 antibody MRP 7 antibody MRP7 antibody TNR CFTR antibody

P13569