Boster Immunoleader

antibody

Anti-TIA1 Antibody

PA2194

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse

Anti-TIA1 Antibody

PA2194

Polyclonal

Rabbit IgG polyclonal antibody for Nucleolysin TIA-1 isoform p40(TIA1) detection. Tested with WB in Human;Mouse.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: human Predicted to work with: mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Human; Predicted Species: Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence at the N-terminus of human TIA1(98-110aa STQRSQDHFHVFV), identical to the related mouse sequence.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

TIA1, also called WDM, encodes an RNA-binding protein involved in splicing regulation and translational repression. The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte(CTL) target cells. By in situ hybridization, this gene is mapped to chromosome 2p13.3. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is though to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.

1. Hackman, P., Sarparanta, J., Lehtinen, S., Vihola, A., Evila, A., Jonson, P. H., Luque, H., Kere, J., Screen, M., Chinnery, P. F., Ahlberg, G., Edstrom, L., Udd, B. Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1. Ann. Neurol. 73: 500-509, 2013. 2. Klar, J., Sobol, M., Melberg, A., Mabert, K., Ameur, A., Johansson, A. C. V., Feuk, L., Entesarian, M., Orlen, H., Casar-Borota, O., Dahl, N. Welander distal myopathy caused by an ancient founder mutation in TIA1 associated with perturbed splicing. Hum. Mutat. 34: 572-577, 2013.

TIA1

Nucleolysin TIA-1 isoform p40

TIA1 cytotoxic granule-associated RNA binding protein

Cytotoxic granule associated RNA binding protein 1 antibody Cytotoxic granule associated RNA binding protein antibody mTIA-1 antibody Nucleolysin TIA 1 isoform p40 antibody Nucleolysin TIA-1 isoform p40 antibody Nucleolysin TIA1 isoform p40 antibodyp40 TIA 1 antibody p40-TIA-1(containing p15-TIA-1) antibody p40-TIA-1 antibody RNA binding protein TIA 1 antibody RNA binding protein TIA1 antibody RNA-binding protein TIA-1 antibody T-cell-restricted intracellular antigen-1 antibody TIA 1 antibody TIA 1 cytotoxic granule associated RNA binding protein antibody Tia antibody TIA-1 antibody TIA1 antibody TIA1 cytotoxic granule associated RNA binding protein antibody TIA1 cytotoxic granule associated RNA binding protein like 1 antibody TIA1 protein antibody TIA1_HUMAN antibody TIAL1 antibody TIAR antibody

P31483