Boster Immunoleader

antibody

Anti-Hes1 Antibody

PA2193

100 ug/vial

200 USD

polyclonal

rabbit

human, mouse, rat

Anti-Hes1 Antibody

PA2193

Polyclonal

Rabbit IgG polyclonal antibody for Transcription factor HES-1(HES1) detection. Tested with WB in Human;Mouse;Rat.

200 USD

Rabbit IgG

100 ug/vial

Lyophilized

No cross reactivity with other proteins.

Reacts with: rat Predicted to work with: human, mouse

WB

Concentration: 0.1-0.5μg/ml; Tested Species: Rat; Predicted Species: Human, Mouse

Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

A synthetic peptide corresponding to a sequence in the middle region of human Hes1(142-155aa HLANCMTQINAMTY), identical to the related mouse and rat sequences.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.

Boster provides a series of assays reacted with primary antibodies. Antibody can be supported by chemiluminescence kit EK1002 in WB.

Transcription factor HES-1, also called HRY or HES-1 is a protein that is encoded by the HES1 gene. This gene belongs to a family of basic helix-loop-helix(bHLH) proteins that are essential for neurogenesis, myogenesis, hematopoiesis, and sex determination. This gene is mapped to 3q29. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. This gene may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. It may play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

1. Fukuda, A., Kawaguchi, Y., Furuyama, K., Kodama, S., Horiguchi, M., Kuhara, T., Koizumi, M., Boyer, D. F., Fujimoto, K., Doi, R., Kageyama, R., Wright, C. V. E., Chiba, T.Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J. Clin. Invest. 116: 1484-1493, 2006. 2. Wendorff, A. A., Koch, U., Wunderlich, F. T., Wirth, S., Dubey, C., Bruning, J. C., MacDonald, H. R., Radtke, F. Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity 33: 671-684, 2010.

HES1

Transcription factor HES-1

hairy and enhancer of split 1,(Drosophila)

bHLHb39 antibody C-HAIRY1 antibody c-hairy1A antibody Class B basic helix-loop-helix protein 39 antibody FLJ20408 antibody Hairy and enhancer of split 1(Drosophila) antibody Hairy and enhancer of split 1 antibody Hairy Enhancer of Split 1 antibody Hairy homolog(Drosophila) antibody Hairy Homolog antibody Hairy like antibody Hairy, Drosophila, homolog of antibody Hairy-like protein antibody Hairy/enhancer of split, Drosophila, homolog of, 1 antibody HAIRY1 antibody HES-1 antibody hes1 antibody Hes1 hairy and enhancer of split 1(Drosophila) antibody HES1_HUMAN antibody HHL antibody HL antibody HRY antibody MGC129109 antibody OTTHUMP00000209031 antibody RHL antibody Transcription factor HES 1 antibody Transcription factor HES-1 antibody

Q14469